• Publications
  • Influence
Regulation of Replication Fork Progression Through Histone Supply and Demand
DNA replication in eukaryotes requires nucleosome disruption ahead of the replication fork and reassembly behind. An unresolved issue concerns how histone dynamics are coordinated with forkExpand
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Chromatin Challenges during DNA Replication and Repair
Inheritance and maintenance of the DNA sequence and its organization into chromatin are central for eukaryotic life. To orchestrate DNA-replication and -repair processes in the context of chromatinExpand
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Regulation of G2/M events by Cdc25A through phosphorylation‐dependent modulation of its stability
DNA replication in higher eukaryotes requires activation of a Cdk2 kinase by Cdc25A, a labile phosphatase subject to further destabilization upon genotoxic stress. We describe a distinct, markedlyExpand
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Chromatin replication and epigenome maintenance
Stability and function of eukaryotic genomes are closely linked to chromatin structure and organization. During cell division the entire genome must be accurately replicated and the chromatinExpand
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  • Open Access
Replication stress interferes with histone recycling and predeposition marking of new histones.
To restore chromatin on new DNA during replication, recycling of histones evicted ahead of the fork is combined with new histone deposition. The Asf1 histone chaperone, which buffers excess histonesExpand
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Nascent chromatin capture proteomics determines chromatin dynamics during DNA replication and identifies unknown fork components
To maintain genome function and stability, DNA sequence and its organization into chromatin must be duplicated during cell division. Understanding how entire chromosomes are copied remains a majorExpand
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  • Open Access
Two distinct modes for propagation of histone PTMs across the cell cycle.
Epigenetic states defined by chromatin can be maintained through mitotic cell division. However, it remains unknown how histone-based information is transmitted. Here we combine nascent chromatinExpand
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  • Open Access
Cyclin-Dependent Kinase Suppression by WEE1 Kinase Protects the Genome through Control of Replication Initiation and Nucleotide Consumption
ABSTRACT Activation of oncogenes or inhibition of WEE1 kinase deregulates cyclin-dependent kinase (CDK) activity and leads to replication stress; however, the underlying mechanism is not understood.Expand
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Human Tousled like kinases are targeted by an ATM‐ and Chk1‐dependent DNA damage checkpoint
All eukaryotes respond to DNA damage by modulation of diverse cellular processes to preserve genomic integrity and ensure survival. Here we identify mammalian Tousled like kinases (Tlks) as a novelExpand
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Histone chaperone networks shaping chromatin function
The association of histones with specific chaperone complexes is important for their folding, oligomerization, post-translational modification, nuclear import, stability, assembly and genomicExpand
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