• Publications
  • Influence
Regulation of noise in the expression of a single gene
Stochastic mechanisms are ubiquitous in biological systems. Biochemical reactions that involve small numbers of molecules are intrinsically noisy, being dominated by large concentration fluctuations.Expand
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spo0J is required for normal chromosome segregation as well as the initiation of sporulation in Bacillus subtilis.
The spo0J gene of Bacillus subtilis is required for the initiation of sporulation. We show that the sporulation defect caused by null mutations in spo0J is suppressed by a null mutation in the geneExpand
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A collection of strains containing genetically linked alternating antibiotic resistance elements for genetic mapping of Escherichia coli.
We present a collection of 182 isogenic strains containing genetically linked antibiotic resistance elements located at approximately 1-min intervals around the Escherichia coli chromosome. At mostExpand
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Genetic networks controlling the initiation of sporulation and the development of genetic competence in Bacillus subtilis.
  • A. Grossman
  • Biology, Medicine
  • Annual review of genetics
  • 1995
Interconnected regulatory networks control the initiation of sporulation and the development of genetic competence in Bacillus subtilis. These two developmental pathways have both common and distinctExpand
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Regulation of a Bacillus subtilis mobile genetic element by intercellular signaling and the global DNA damage response.
Horizontal gene transfer contributes to the evolution of bacterial species. Mobile genetic elements play an important role in horizontal gene transfer, and characterization of the regulation of theseExpand
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Identification and characterization of a negative regulator of FtsZ ring formation in Bacillus subtilis.
During the bacterial cell cycle, the tubulin-like cell-division protein FtsZ polymerizes into a ring structure that establishes the location of the nascent division site. We have identified aExpand
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Spx-dependent global transcriptional control is induced by thiol-specific oxidative stress in Bacillus subtilis
The Spx protein of Bacillus subtilis represses activator-stimulated transcription by interacting with the C-terminal domain of RNA polymerase (RNAP) α subunit. Its concentration increases in cellsExpand
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Localization of bacterial DNA polymerase: evidence for a factory model of replication.
Two general models have been proposed for DNA replication. In one model, DNA polymerase moves along the DNA (like a train on a track); in the other model, the polymerase is stationary (like aExpand
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Purification and characterization of an extracellular peptide factor that affects two different developmental pathways in Bacillus subtilis.
We have purified and characterized an extracellular peptide factor that serves as a cell density signal for both competence development and sporulation in Bacillus subtilis. This competence andExpand
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Identification and Characterization of a Bacterial Chromosome Partitioning Site
We have identified a DNA site involved in chromosome partitioning in B. subtilis. This site was identified in vivo as the binding site for the chromosome partitioning protein Spo0J, a member of theExpand
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