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Notch signaling modulates proliferation and differentiation of intestinal crypt base columnar stem cells
TLDR
It is shown in mice that Notch directly targets the crypt base columnar (CBC) cell to maintain stem cell activity and to regulate cell fate choice to control epithelial cell homeostasis. Expand
Reverse genetic screening reveals poor correlation between morpholino-induced and mutant phenotypes in zebrafish.
TLDR
It is suggested that mutant phenotypes become the standard metric to define gene function in zebrafish, after which Morpholinos that recapitulate respective phenotypes could be reliably applied for ancillary analyses. Expand
Hedgehog-responsive mesenchymal clusters direct patterning and emergence of intestinal villi
TLDR
It is concluded that Hh signals dictate the initial aspects of the formation of each villus by controlling mesenchymal cluster aggregation and regulating cluster size. Expand
Paracrine Hedgehog signaling in stomach and intestine: new roles for hedgehog in gastrointestinal patterning.
TLDR
These studies reveal a previously unrecognized association of paracrine Hedgehog signaling with several gastrointestinal patterning events involving the serosa, pylorus, and villus smooth muscle. Expand
Cell dynamics in fetal intestinal epithelium: implications for intestinal growth and morphogenesis
TLDR
It is demonstrated that growth of epithelial girth between E12.5 and E14.5 is driven by microtubule- and actinomyosin-dependent apicobasal elongation, rather than by progressive epithelial stratification as was previously thought, which favors an alternative model of intestinal morphogenesis. Expand
Gastric tuft cells express DCLK1 and are expanded in hyperplasia
TLDR
Gastric tuft cells appear in the gastric antrum and intestine at E18.5, but their maximal numbers in the corpus are not achieved until after weaning, and numbers increase with inflammation, hyperplasia, and metaplasia. Expand
Separate and distinctive roles for Wnt5a in tongue, lingual tissue and taste papilla development.
TLDR
It is suggested that Wnt5a antagonizes canonical Wnt signaling to dictate papilla number and spacing, demonstrating that the genetic regulation for tongue size and shape can be separated from that directing lingual papilla development. Expand
Coordination of signaling and tissue mechanics during morphogenesis of murine intestinal villi: a role for mitotic cell rounding.
TLDR
Simulations and in vivo data reveal that proper apical membrane invagination involves intraepithelial compressive forces, mitotic cell rounding in the compressed regions and apico-basal contraction of the dividing cell, which establishes a new model that explains how signaling events intersect with tissue forces to pattern apical membranes invaginations that define the villus boundaries. Expand
Radial glia regulate vascular patterning around the developing spinal cord
TLDR
These findings identify CNS-resident progenitors as critical angiogenic regulators that determine the precise patterning of the vasculature around the spinal cord, providing novel insights into vascular network formation around developing organs. Expand
foxc1 is required for embryonic head vascular smooth muscle differentiation in zebrafish.
TLDR
The data suggests that foxc1 is a marker of vSMCs and plays a critical functional role in promoting their differentiation, and an enriched intersectional gene expression profile using dual expression of foxc 1b and acta2 to identify novel vS MC markers is determined. Expand
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