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5-Fluorouracil induces apoptosis in rat cardiocytes through intracellular oxidative stress
BackgroundCardiotoxicity is a major complication of anticancer drugs, including anthracyclines and 5-fluorouracil(5-FU) and it can have detrimental effects both in patients and workers involved inExpand
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Immune responses of Octopus vulgaris (Mollusca: Cephalopoda) exposed to titanium dioxide nanoparticles ☆
Abstract Intramuscular injections of titanium dioxide nanoparticles (nTiO 2 ) at two concentrations (1 and 10 mg/kg) induced short-term immune response in the cephalopod mollusk Octopus vulgaris .Expand
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Molecular targets for the treatment of multiple myeloma.
Multiple myeloma (MM) represents a suitable disease to be treated with Molecularly targeted drugs (MTDs). MM clone aberrations affect signal transduction pathways controlling both proliferationExpand
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Radiogenomic Analysis of Oncological Data: A Technical Survey
In the last few years, biomedical research has been boosted by the technological development of analytical instrumentation generating a large volume of data. Such information has increased inExpand
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Vascular-homing peptides for targeted drug delivery and molecular imaging: meeting the clinical challenges.
The vasculature of each organ expresses distinct molecular signatures critically influenced by the pathological status. The heterogeneous profile of the vascular beds has been successfully unveiledExpand
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pEGFR-Tyr 845 expression as prognostic factors in oral squamous cell carcinoma
The EGFR (epidermal growth factor receptor) a member of the family of transmembrane protein kinase receptors known as the erbB family shows a significant correlation with the presence of metastasesExpand
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Nanoparticle-based strategies for cancer immunotherapy and immunodiagnostics.
Although recent successes in clinical trials are strengthening research focused on cancer immunology, the poor immunogenicity and off-target side effects of immunotherapeutics remain major challengesExpand
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Non-coding RNAs as a new dawn in tumor diagnosis.
The current knowledge about non-coding RNAs (ncRNAs) as important regulators of gene expression in both physiological and pathological conditions, has been the main engine for the design ofExpand
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Pharmacological inhibition of HSP90 and ras activity as a new strategy in the treatment of HNSCC
Advanced head and neck squamous cell cancer (HNSCC) is currently treated with taxane‐based chemotherapy. We have previously shown that docetaxel (DTX) induces a ras‐dependent survival signal that canExpand
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Biobanking in health care: evolution and future directions
BackgroundThe aim of the present review is to discuss how the promising field of biobanking can support health care research strategies. As the concept has evolved over time, biobanks have grown fromExpand
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