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Chromatography-mass spectrometry studies on the metabolism of synthetic cannabinoids JWH-018 and JWH-073, psychoactive components of smoking mixtures.
TLDR
Using gas and liquid chromatography-mass spectrometry, a series of metabolites in urine samples from humans and rats were identified that were products of the following reactions: mono- and dihydroxylation of the parent compounds with hydroxyl groups located at aromatic and aliphatic residues. Expand
Gas and liquid chromatography-mass spectrometry detection of the urinary metabolites of UR-144 and its major pyrolysis product.
TLDR
The detection of mono-hydroxylated metabolites of UR-144 (LC-MS-MS) and mono-Hydroxylation/with hydration metabolites of the UR- 144 pyrolysis product (GC- MS) was found to be the most useful method of establishingUR-144 ingestion. Expand
Gas and liquid chromatography-mass spectrometry studies on the metabolism of the synthetic phenylacetylindole cannabimimetic JWH-250, the psychoactive component of smoking mixtures.
TLDR
The detection of the mono- and dihydroxylated metabolites of JWH-250 in urine and serum samples by GC-MS and LC-MS/MS proved to be effective in determining consumption of this drug. Expand
The detection of the urinary metabolites of 1-[(5-fluoropentyl)-1H-indol-3-yl]-(2-iodophenyl)methanone (AM-694), a high affinity cannabimimetic, by gas chromatography - mass spectrometry.
TLDR
Using gas chromatography-mass spectrometry (GC-MS), six metabolites were identified in post-ingestion samples of AM-694, a synthetic indole-based cannabimimetic, and one metabolite (a product of hydrolytic defluorination) was also identified in urine samples from two individuals admitted to hospital suffering from suspected drug overdoses. Expand
UR-144 in products sold via the Internet: identification of related compounds and characterization of pyrolysis products.
TLDR
The synthetic cannabinoid, UR-144, was identified in commercial 'legal high' products (herbal, resin, and powder) and six related compounds were detected, including the most abundant one (2.1), which was found to be undergo cyclisation which leads to the formation of two additional interconvertable compounds. Expand
The identification of the urinary metabolites of 3-(4-methoxybenzoyl)-1-pentylindole (RCS-4), a novel cannabimimetic, by gas chromatography-mass spectrometry.
TLDR
The O-demethylated metabolites were found to be the most useful metabolic markers for the identification of RCS-4 ingestion. Expand
The detection of the urinary metabolites of 3-[(adamantan-1-yl)carbonyl]-1-pentylindole (AB-001), a novel cannabimimetic, by gas chromatography-mass spectrometry.
TLDR
The urinary metabolites of AB-001, a synthetic cannabimimetic identified in head shop products in Ireland in 2010, have been identified and found to be adamantane mono-hydroxylated and adamantane Mono-Hydroxylation/N-dealkylated products. Expand
Detection and tentative identification of urinary phase I metabolites of phenylacetylindole cannabimimetics JWH-203 and JWH-251, by GC-MS and LC-MS/MS.
TLDR
The monohydroxylated metabolites with the hydroxyl group positioned on the N-pentyl chain were the most abundant and were found to be suitable for establishing ingestion of JWH-203 orJWH-250. Expand
Detection of metabolites of two synthetic cannabimimetics, MDMB-FUBINACA and ADB-FUBINACA, in authentic human urine specimens by accurate mass LC–MS: a comparison of intersecting metabolic patterns
The structures of two indazole-derived synthetic cannabimimetics, a methyl ester, MDMB-FUBINACA, and an amide, ADB-FUBINACA, differ only in the terminal groups on the side chains. Based upon liquidExpand
Human urinary metabolite pattern of a new synthetic cannabimimetic, methyl 2-(1-(cyclohexylmethyl)-1H-indole-3-carboxamido)-3,3-dimethylbutanoate
A number of metabolites of a new synthetic cannabimimetic, which is a derivative of 2-(1-(cyclohexylmethyl)-1H-indole-3-carboxamido)-3,3-dimethylbutanoic acid, were identified in human urine. TheExpand
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