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Transcriptome analysis of mammary epithelial subpopulations identifies novel determinants of lineage commitment and cell fate
BackgroundUnderstanding the molecular control of cell lineages and fate determination in complex tissues is key to not only understanding the developmental biology and cellular homeostasis of suchExpand
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FGFR1 Emerges as a Potential Therapeutic Target for Lobular Breast Carcinomas
Purpose: Classic lobular carcinomas (CLC) account for 10% to 15% of all breast cancers. At the genetic level, CLCs show recurrent physical loss of chromosome16q coupled with the lack of E-cadherinExpand
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A Distinct Spectrum of Copy Number Aberrations in Pediatric High-Grade Gliomas
Purpose: As genome-scale technologies begin to unravel the complexity of the equivalent tumors in adults, we can attempt detailed characterization of high-grade gliomas in children, that have untilExpand
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Genomic Complexity Profiling Reveals That HORMAD1 Overexpression Contributes to Homologous Recombination Deficiency in Triple-Negative Breast Cancers.
UNLABELLED Triple-negative breast cancers (TNBC) are characterized by a wide spectrum of genomic alterations, some of which might be caused by defects in DNA repair processes such as homologousExpand
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Array CGH profiling of favourable histology Wilms tumours reveals novel gains and losses associated with relapse
Despite the excellent survival of Wilms tumour patients treated with multimodality therapy, approximately 15% will suffer from tumour relapse, where response rates are markedly reduced. We haveExpand
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Selectin ligand sialyl-Lewis x antigen drives metastasis of hormone-dependent breast cancers.
The glycome acts as an essential interface between cells and the surrounding microenvironment. However, changes in glycosylation occur in nearly all breast cancers, which can alter this interaction.Expand
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Comparison of basal-like triple-negative breast cancer defined by morphology, immunohistochemistry and transcriptional profiles
Basal-like invasive breast cancer is an important clinical group because of its association with a triple-negative phenotype defined by the lack of expression of estrogen, progesterone and humanExpand
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Molecular characterisation of cell line models for triple-negative breast cancers
BackgroundTriple-negative breast cancers (BC) represent a heterogeneous subtype of BCs, generally associated with an aggressive clinical course and where targeted therapies are currently limited.Expand
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Expression profiling of purified normal human luminal and myoepithelial breast cells: identification of novel prognostic markers for breast cancer.
The normal duct-lobular system of the breast is lined by two epithelial cell types, inner luminal secretory cells and outer contractile myoepithelial cells. We have generated comprehensive expressionExpand
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Tiling Path Genomic Profiling of Grade 3 Invasive Ductal Breast Cancers
Purpose: To characterize the molecular genetic profiles of grade 3 invasive ductal carcinomas of no special type using high-resolution microarray-based comparative genomic hybridization (aCGH) and toExpand
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