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Thrombotic Thrombocytopenia after ChAdOx1 nCov-19 Vaccination
TLDR
Vaccination with Ch adenoviral vector encoding the spike protein antigen of severe acute respiratory syndrome coronavirus 2 can result in the rare development of immuneThrombotic thrombocytopenia mediated by platelet-activating antibodies against PF4, which clinically mimics autoimmune heparin-induced thromBocy topenia.
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Heparin-induced thrombocytopenia: recognition, treatment, and prevention: the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy.
This chapter about the recognition, treatment, and prevention of heparin-induced thrombocytopenia (HIT) is part of the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy: Evidence…
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Treatment and prevention of heparin-induced thrombocytopenia: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition).
This chapter about the recognition, treatment, and prevention of heparin-induced thrombocytopenia (HIT) is part of the Antithrombotic and Thrombolytic Therapy: American College of Chest Physicians…
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Evaluation of pretest clinical score (4 T's) for the diagnosis of heparin‐induced thrombocytopenia in two clinical settings
TLDR
A low pretest clinical score for HIT seems to be suitable for ruling out HIT in most situations (high‐negative predictive value), and the implications of an intermediate or high score vary in different clinical settings.
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American Society of Hematology 2018 guidelines for management of venous thromboembolism: heparin-induced thrombocytopenia.
TLDR
These evidence-based guidelines of the American Society of Hematology are intended to support patients, clinicians, and other health care professionals in their decisions about diagnosis and management of HIT.
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Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium
TLDR
This study has identified new determinants of erythrocyte traits, offering insight into common variants underlying variation in ery throatcyte measures, and identifies 23 loci significantly associated with these traits.
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A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium
TLDR
A long-range haplotype at 12q24 associated with coronary artery disease and myocardial infarction is identified and it is shown that this haplotype demonstrates extensive disease pleiotropy, as it contains known risk loci for type 1 diabetes, hypertension and celiac disease and has been spread by a selective sweep specific to European and geographically nearby populations.
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Autoimmune heparin‐induced thrombocytopenia
TLDR
Non‐APTT‐adjusted therapies with drugs such as danaparoid and fondaparinux, or even direct oral anticoagulants, such as rivaroxaban or apixaban, are suggested therapies, especially for long‐term management of persisting HIT.
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CLINICAL PRACTICE. Heparin-Induced Thrombocytopenia.
  • A. Greinacher
  • Medicine
    The New England journal of medicine
  • 16 July 2015
A 64-year-old woman who is hospitalized with endocarditis and whose condition is clinically stable while she is receiving intravenous antibiotic agents has had a decrease in platelet count from…
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Heparin-induced thrombocytopenia and cardiac surgery.
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