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ADHD-200 Global Competition: diagnosing ADHD using personal characteristic data can outperform resting state fMRI measurements
Neuroimaging-based diagnostics could potentially assist clinicians to make more accurate diagnoses resulting in faster, more effective treatment. We participated in the 2011 ADHD-200 GlobalExpand
Relationship of plasma amphetamine levels to physiological, subjective, cognitive and biochemical measures in healthy volunteers
Acute administration of the stimulant dextro‐amphetamine produces multiple physiological, subjective cognitive and biochemical changes. These effects are similar to those seen in mania, and may be aExpand
Accuracy of automated classification of major depressive disorder as a function of symptom severity
Background Growing evidence documents the potential of machine learning for developing brain based diagnostic methods for major depressive disorder (MDD). As symptom severity may influence brainExpand
5-HT receptors and reward-related behaviour: A review
The brain's serotonin (5-HT) system is key in the regulation of reward-related behaviours, from eating and drinking to sexual activity. The complexity of studying this system is due, in part, to theExpand
Nicotine-induced decreases in VTA electrical self-stimulation thresholds: blockade by haloperidol and mecamylamine but not scopolamine or ondansetron
Abstract The effects of repeated daily injections of (–)-nicotine (+) hydrogen tartrate (mg kg–1 SC) on electrical self-stimulation of the ventral tegmental area were investigated. Nicotine reducedExpand
Effects of systemic and intra-nucleus accumbens 5-HT2C receptor compounds on ventral tegmental area self-stimulation thresholds in rats
RationaleSerotonin 2C (5-HT2C) receptors may play a role in regulating motivation and reward-related behaviours. To date, no studies have investigated the possible role of 5-HT2C receptors in ventralExpand
Differential effects of 5-HT2C receptor activation by WAY 161503 on nicotine-induced place conditioning and locomotor activity in rats
RATIONALE Numerous studies indicate a role for both the serotonin 2C receptor (5-HT(2C)) and the nicotinic acetylcholine receptor in locomotion, reinforcement and motivated behaviours. Nicotine, aExpand
COVID-19 Pandemic: Age-Related Differences in Measures of Stress, Anxiety and Depression in Canada
Background: The spread of COVID-19 along with strict public health measures have resulted in unintended adverse effects, including greater levels of distress, anxiety, and depression. This studyExpand
Reciprocal changes in striatal dopamine and β-phenylethylamine induced by reserpine in the presence of monoamine oxidase inhibitors
SummaryRecent studies have demonstrated that selective monoamine oxidase inhibition may induce changes in brain β-phenylethylamine availability following lesions. The present study used this approachExpand
COVID-19 Pandemic and Mental Health: Prevalence and Correlates of New-Onset Obsessive-Compulsive Symptoms in a Canadian Province
Background: This cross-sectional online survey investigates the prevalence of obsessive-compulsive disorder (OCD) symptoms at an early stage of the COVID-19 pandemic in Canada. Methods: OCD symptoms,Expand