• Publications
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ADHD-200 Global Competition: diagnosing ADHD using personal characteristic data can outperform resting state fMRI measurements
TLDR
Surprisingly, this approach achieved the highest diagnostic accuracy as well as the highest score of any of the 21 teams participating in the 2011 ADHD-200 Global Competition, demonstrating the importance of accounting for differences in age, gender, and other personal characteristics in imaging diagnostics research.
Relationship of plasma amphetamine levels to physiological, subjective, cognitive and biochemical measures in healthy volunteers
TLDR
While dextro‐amphetamine administration definitely causes several changes which are seen in mania, there remain some physiological and metabolic differences between these two conditions.
Nicotine-induced decreases in VTA electrical self-stimulation thresholds: blockade by haloperidol and mecamylamine but not scopolamine or ondansetron
TLDR
Repeated daily administration of (–)-nicotine increases the rewarding effects of electrical self-stimulation of the ventral tegmental area, consistent with the proposal that repeated daily injections of nicotine positively effect a mesolimbic dopaminergic substrate of reward.
After the Fort McMurray wildfire there are significant increases in mental health symptoms in grade 7–12 students compared to controls
TLDR
The results demonstrate that mental health symptoms were statistically significantly elevated in the Fort McMurray population when compared to the control population in Red Deer, and highlight the need to identify adolescents most at risk of developing psychiatric symptoms after experiencing the trauma of disaster.
COVID-19 Pandemic: Age-Related Differences in Measures of Stress, Anxiety and Depression in Canada
TLDR
The finding that the prevalence rates and the mean scores for stress, anxiety, and depression on standardized scales to decrease from younger to older subscribers is an interesting observation with potential implications for planning to meet mental health service needs during COVID-19.
Effects of systemic and intra-nucleus accumbens 5-HT2C receptor compounds on ventral tegmental area self-stimulation thresholds in rats
TLDR
The results suggest that 5-HT2C receptors play an inhibitory role in regulating reward-related behaviour while 5- HT2C receptor activation in the NAc shell did not appear to influence VTA ICSS behaviour under the present experimental conditions.
COVID-19 Pandemic and Mental Health: Prevalence and Correlates of New-Onset Obsessive-Compulsive Symptoms in a Canadian Province
TLDR
The prevalence of OCD symptoms increased during the COVID-19 pandemic, at a rate significantly higher than pre-pandemic rates reported for the sample population, and presented with elevated stress, likely GAD, and likely MDD.
Acute fluoxetine treatment potentiates amphetamine hyperactivity and amphetamine-induced nucleus accumbens dopamine release: possible pharmacokinetic interaction
TLDR
It is shown that acute fluoxetine treatment potentiates the locomotor stimulating and dopamine activating effects of amphetamine, probably through inhibition of cytochrome P450 isozymes.
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