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A family of cAMP-binding proteins that directly activate Rap1.
TLDR
The findings suggest the need to reformulate concepts of cAMP-mediated signaling to include direct coupling to Ras superfamily signaling. Expand
Habits, rituals, and the evaluative brain.
  • A. Graybiel
  • Psychology, Medicine
  • Annual review of neuroscience
  • 17 June 2008
TLDR
This review suggests that many of these behaviors could emerge as a result of experience-dependent plasticity in basal ganglia-based circuits that can influence not only overt behaviors but also cognitive activity. Expand
The substantia nigra of the human brain. II. Patterns of loss of dopamine-containing neurons in Parkinson's disease.
TLDR
The spatiotemporal progression of neuronal loss related to disease duration can be drawn in the substantia nigra pars compacta for each Parkinson's disease patient: depletion begins in the main pocket (nigrosome 1) and then spreads to other nigrosomes and the matrix along rostral, medial and dorsal axes of progression. Expand
Dynamic cross-frequency couplings of local field potential oscillations in rat striatum and hippocampus during performance of a T-maze task
TLDR
Cross-frequency coupling of multiple neuronal rhythms could be a general mechanism used by the brain to perform network-level dynamical computations underlying voluntary behavior, particularly during decision-making behavioral epochs. Expand
Cell type–specific channelrhodopsin-2 transgenic mice for optogenetic dissection of neural circuitry function
TLDR
This resource of cell type–specific ChR2(H134R) mouse lines will facilitate the precise mapping of neuronal connectivity and the dissection of the neural basis of behavior. Expand
Neurotransmitters and neuromodulators in the basal ganglia
  • A. Graybiel
  • Biology, Medicine
  • Trends in Neurosciences
  • 1 July 1990
TLDR
A new view of the basal ganglia is emerging on the basis of this neurochemical heterogeneity, suggesting that dynamic regulation of transmitter expression may be a key to extrapyramidal function. Expand
The Basal Ganglia and Chunking of Action Repertoires
  • A. Graybiel
  • Psychology, Medicine
  • Neurobiology of Learning and Memory
  • 1 July 1998
TLDR
It is proposed that one aspect of basal ganglia-based learning is the recoding of cortically derived information within the striatum that can chunk the representations of motor and cognitive action sequences so that they can be implemented as performance units. Expand
Activity of striatal neurons reflects dynamic encoding and recoding of procedural memories
TLDR
It is proposed that changes in task representation in cortico-basal ganglia circuits represent neural equivalents of the explore–exploit behaviour characteristic of habit learning. Expand
Neurons in the thalamic CM-Pf complex supply striatal neurons with information about behaviorally significant sensory events.
TLDR
It is suggested that neurons in the CM and Pf supplystriatal neurons with information about behaviorally significant sensory events that can activate conditional responses of striatal neurons in combination with dopamine-mediated nigrostriatal inputs having motivational value. Expand
Amphetamine and cocaine induce drug-specific activation of the c-fos gene in striosome-matrix compartments and limbic subdivisions of the striatum.
TLDR
It is proposed that differential activation of immediate-early genes by psychostimulants may be an early step in drug-specific molecular cascades contributing to acute and long-lasting psychostIMulant-induced changes in behavior. Expand
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