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Ca2+‐independent insulin exocytosis induced by α‐latrotoxin requires latrophilin, a G protein‐coupled receptor
α‐Latrotoxin (α‐LTX) induces exocytosis of small synaptic vesicles (SSVs) in neuronal cells both by a calcium‐independent mechanism and by opening cation‐permeable pores. Since the basic molecularExpand
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A protein induced by NGF in PC12 cells is stored in secretory vesicles and released through the regulated pathway.
We have previously described the isolation of a cDNA clone corresponding to an mRNA rapidly induced to high levels in PC12 cells by treatment with NGF. We report here the complete amino acid sequenceExpand
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First dual aromatase-steroid sulfatase inhibitors.
Aromatase inhibitors in clinical use block the biosynthesis of estrogens. Hydrolysis of estrone 3-sulfate by steroid sulfatase is an important additional source of tumor estrogen, and blockade ofExpand
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A functional domain on the alpha-latrotoxin molecule, distinct from the binding site, involved in catecholamine secretion from PC12 cells: identification with monoclonal antibodies.
Seven monoclonal antibodies (mAbs) have been produced against alpha-latrotoxin (alpha-Latx), the toxin component of black widow spider venom that stimulates release of neurotransmitters from PC12Expand
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The effect of altered carbohydrate metabolism in pertussis-sensitized mice on anaphylaxis.
Abstract An attenuated reponse to epinephrine-induced hyperglycemia has been demonstrated in rats injected with Bordetella pertussis alone and in mice sensitized with horse serum or in combinationExpand
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Expression of a specific neuronal protein, 14-3-2, during in vitro differentiation of neuroblastoma cells.
Abstract Expression of the neuronal marker 14-3-2 or NSE (neuron-specific enolase) has been studied during in vitro differentiation of cells in culture. The 14-3-2 protein of neuroblastoma cells isExpand
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Neuroblastoma cells and 14-3-2, a brain specific protein.
Abstract 14-3-2, a nervous system specific protein, has been studied in mouse neuroblastoma cells grown in culture by means of the microcomplement fixation assay. The experiments reported indicateExpand
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Occupational Exposure to Solar UV Radiation of a Group of Fishermen Working in the Italian North Adriatic Sea
Occupational solar radiation exposure is a relevant heath risk in the fishing sector. Our aim was to provide a detailed evaluation of individual UV exposure in three different fishing activities inExpand
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14-3-2 Protein in rat primary and transplanted gliomas and neurinomas and in clonal cell lines
SummaryExperimental neurogenic tumors were induced transplacentally in rats by single injections of ethylnitrosourea (ENU). The resulting primary tumors as well as isogenic transplantation tumorExpand
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