Defects in enteric innervation and kidney development in mice lacking GDNF
It is demonstrated that GDNF induces ureter bud formation and branching during metanephros development, and is essential for proper innervation of the gastrointestinal tract.
Long-Term Environmental Enrichment Leads to Regional Increases in Neurotrophin Levels in Rat Brain
- B. Ickes, T. Pham, L. Sanders, D. Albeck, A. Mohammed, A. Granholm
- Biology, PsychologyExperimental Neurology
- 1 July 2000
Findings demonstrate significant alterations in NGF, BDNF, and NT-3 protein levels in several brain regions as a result of an enriched versus an isolated environment and thus provide a possible biochemical basis for behavioral and morphological alterations that have been found to occur with a shifting environmental stimulus.
Loss of Cholinergic Phenotype in Basal Forebrain Coincides with Cognitive Decline in a Mouse Model of Down's Syndrome
The loss of ChAT-immunoreactive neurons in the basal forebrain was coupled with simultaneous deficits in behavioral flexibility on a spatial task occurring for the first time around 6 months of age, suggesting that the loss of cholinergic function and the simultaneous decrease in trkA immunoreactivity in basal fore brain may directly correlate with cognitive impairment in the Ts65Dn mouse.
Histologic validation of locus coeruleus MRI contrast in post-mortem tissue
Glial cell line-derived neurotrophic factor augments midbrain dopaminergic circuits in vivo
At the interface of sensory and motor dysfunctions and Alzheimer's disease
Resolution of inflammation is altered in Alzheimer's disease
Testosterone, but not nonaromatizable dihydrotestosterone, improves working memory and alters nerve growth factor levels in aged male rats
Damaging effects of a high-fat diet to the brain and cognition: A review of proposed mechanisms
- L. Freeman, V. Haley-Zitlin, D. Rosenberger, A. Granholm
- Medicine, PsychologyNutritional neuroscience
- 17 September 2014
Various mechanisms by which a high fat diet and/or obesity can alter the brain and cognition are discussed and it is very likely that each of these factors plays a role in diet-induced and/ or obesity-induced cognitive decline.
Pro-Resolving Lipid Mediators Improve Neuronal Survival and Increase Aβ42 Phagocytosis
In vitro studies showed that lipoxin A4, MaR1, resolvin D1 (RvD1), and protectin DX (PDX) exerted neuroprotective activity, and thatMaR1 and RvD 1 down-regulated β-amyloid (Aβ)42-induced inflammation in human microglia, indicating that stimulating this pathway is a promising treatment strategy for AD.