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Effects of NADPH oxidase inhibitor in diabetic nephropathy.
Activation of NADPH oxidase with translocation of p47phox to the membrane underlies the oxidative stress and limited NO generation, despite enhanced eNOS expression in a model of diabetic nephropathy.
Oxidative stress and nitric oxide synthase in rat diabetic nephropathy: effects of ACEI and ARB.
Early proteinuric diabetic nephropathy increases renal expression of the p47phox component of NAD(P)H oxidase and eNOS with increased indices of systemic and renal oxidative/nitrosative stress, which indicates a pathogenic role for AT1 receptors in the development of oxidative damage in the kidneys during early DM.
Urinary fatty acid-binding protein as a new clinical marker of the progression of chronic renal disease.
Urinary L-FABP reflected the clinical prognosis of chronic renal disease and may be a clinical marker that can help predict the progression of chronic glomerular disease.
Adrenomedullin Induces Endothelium-Dependent Vasorelaxation via the Phosphatidylinositol 3-Kinase/Akt-Dependent Pathway in Rat Aorta
Results suggested that AM induced Akt activation in the endothelium via the Ca2+/calmodulin-dependent pathway and that this was implicated in the production of NO, which in turn induced endothelia-dependent vasodilation in rat aorta.
Dual blockade of aldosterone and angiotensin II additively suppresses TGF-beta and NADPH oxidase in the hypertensive kidney.
The association of Eplerenone to ACEI is beneficial due to further reduction of NADPH oxidase and specific inhibition of TGF-beta resulting in improvement of renal damage.
Long-term inhibition of renin-angiotensin system sustains memory function in aged Dahl rats.
Long-term treatment with an ACE inhibitor improves memory dysfunction probably through restoration of capillary and hippocampal cells and probably to the enhancement of the kallikrein-kinin system.
Brain lesions in the paraventricular nuclei and catecholaminergic neurons minimize salt hypertension in Dahl salt-sensitive rats.
The results show that NaCl-induced hypertension in Dahl salt-sensitive rats requires the integrity of the central nervous system catecholaminergic neurones and the paraventricular nuclei for its full expression.
Prolonged inhibition of vascular contraction and calcium influx by the novel 1,4-dihydropyridine calcium antagonist cinaldipine (FRC-8653).
It is suggested that prolonged inhibition of calcium influx through L-channels contributes to the long-lasting vasodilative and antihypertensive activity of FRC-8653.
Reduced albumin reabsorption in the proximal tubule of early-stage diabetic rats
Abstract. The aim of this study is to investigate the role of the proximal tubule in microalbuminuria in the early stage of diabetic nephropathy. Diabetes was induced in male Sprague-Dawley rats by
Hypoxia-induced adrenomedullin production in the kidney.
Renal parenchymal cells as well as renal vessels may produce AM under hypoxic conditions.