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Anxiogenic effects of acute and chronic cocaine administration: Neurochemical and behavioral studies
- Xiao-Min Yang, A. Gorman, A. Dunn, N. Goeders
- Medicine, PsychologyPharmacology Biochemistry and Behavior
- 1 March 1992
Evidence for an acute anxiogenic effect of cocaine was obtained from mice studied in the elevated plus-maze and acute cocaine administration decreased both the number of entries into and the time spent in the open arms of the maze.
The d- and l- isomers of methadone bind to the non-competitive site on the N-methyl-d-aspartate (NMDA) receptor in rat forebrain and spinal cord
Internal effects of divalent cations on potassium permeability in molluscan neurones.
It is concluded that the effectiveness of a divalent cation in activating the K current is, in part, related to its ionic radius, and that the site of activation can accommodate ionic radii between about 0.76 and 1.13 A.
Effects of tetraethylammonium on potassium currents in a molluscan neurons
The effects of tetraethylammonium (TEA) on the delayed K+ current and on the Ca2+-activated K+ current of the Aplysia pacemaker neurons R-15 and L-6 were studied. The delayed outward K+ current was…
Potassium conductance and internal calcium accumulation in a molluscan neurone
1. The Aplysia neurone R‐15 was injected with the Ca2+ sensitive dye arsenazo III. Changes in dye absorbance were measured with a differential spectrophotometer to monitor changes in the free…
Ionic requirements for membrane oscillations and their dependence on the calcium concentration in a molluscan pace‐maker neurone
Membrane currents from the bursting pace‐maker neurone R‐15 of Aplysia were measured under conditions designed to simulate membrane oscillations to monitor changes in the free intracellular Ca2+ concentration, [Ca]i.
Intracellular calcium accumulation during depolarization in a molluscan neurone.
The results suggest that the slow decrease in dye absorbance during prolonged depolarization is caused by inactivation of the Ca2+ channel.
Changes in the intracellular concentration of free calcium ions in a pace‐maker neurone, measured with the metallochromic indicator dye arsenazo III.
It is suggested that Ca2+ enters during the pace‐maker cycle, thereby increasing [Ca]i, and that this increase is sufficient to activate an outward current carried by K+ ions which causes or contributes to the post‐burst hyperpolarization.
Photoreceptor Potentials of Opposite Polarity in the Eye of the Scallop, Pecten irradians
The evidence suggests that the depolarizing responses are from the microvilli-brearing proximal cells, and the hyperpolarized responses from the ciliary-type distal cells of the retina, and that both responses are directly produced by light.
Differential patterns of activation of the pyramidal system elicited by surface anodal and cathodal cortical stimulation.
- A. Gorman
- Psychology, MedicineJournal of neurophysiology
- 1 July 1966