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- Publications
- Influence
Genetic studies of body mass index yield new insights for obesity biology
- A. Locke, Bratati Kahali, +479 authors E. K. Speliotes
- Biology, Medicine
- Nature
- 12 February 2015
Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity better, here we conduct a genome-wide association study and Metabochip meta-analysis of body mass… Expand
Large-scale association analysis identifies new risk loci for coronary artery disease
- P. Deloukas, S. Kanoni, +180 authors N. Samani
- Biology, Medicine
- Nature Genetics
- 2013
Coronary artery disease (CAD) is the commonest cause of death. Here, we report an association analysis in 63,746 CAD cases and 130,681 controls identifying 15 loci reaching genome-wide significance,… Expand
A comprehensive 1000 Genomes-based genome-wide association meta-analysis of coronary artery disease
- M. Nikpay, A. Goel, +148 authors M. Farrall
- Biology, Medicine
- Nature Genetics
- 27 August 2015
Existing knowledge of genetic variants affecting risk of coronary artery disease (CAD) is largely based on genome-wide association study (GWAS) analysis of common SNPs. Leveraging phased haplotypes… Expand
DNA methylation and body-mass index: a genome-wide analysis
BACKGROUND
Obesity is a major health problem that is determined by interactions between lifestyle and environmental and genetic factors. Although associations between several genetic variants and… Expand
White Cell Telomere Length and Risk of Premature Myocardial Infarction
- S. Brouilette, R. K. Singh, J. Thompson, A. Goodall, N. Samani
- Medicine
- Arteriosclerosis, thrombosis, and vascular…
- 1 May 2003
Objective—Biological age may be distinct from chronological age and contribute to the pathogenesis of age-related diseases. Mean telomeres lengths provide an assessment of biological age with shorter… Expand
A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium
- N. Soranzo, T. Spector, +77 authors C. Gieger
- Biology, Medicine
- Nature Genetics
- 1 November 2009
The number and volume of cells in the blood affect a wide range of disorders including cancer and cardiovascular, metabolic, infectious and immune conditions. We consider here the genetic variation… Expand
Telomere shortening in atherosclerosis
- N. Samani, R. Boultby, R. Butler, J. Thompson, A. Goodall
- Biology, Medicine
- The Lancet
- 11 August 2001
Eukaryotic chromosomes end with telomeres, which shorten with cellular ageing. We investigated whether atherosclerosis is associated with systemic evidence of accelerated cellular ageing. We compared… Expand
Repeated Replication and a Prospective Meta-Analysis of the Association Between Chromosome 9p21.3 and Coronary Artery Disease
- H. Schunkert, A. Goetz, +31 authors N. Samani
- Medicine
- Circulation
- 1 April 2008
Background— Recently, genome-wide association studies identified variants on chromosome 9p21.3 as affecting the risk of coronary artery disease (CAD). We investigated the association of this locus… Expand
A genome-wide association study identifies two loci associated with heart failure due to dilated cardiomyopathy.
- E. Villard, C. Perret, +41 authors F. Cambien
- Medicine
- European heart journal
- 1 May 2011
AIMS
Dilated cardiomyopathy (DCM) is a major cause of heart failure with a high familial recurrence risk. So far, the genetics of DCM remains largely unresolved. We conducted the first genome-wide… Expand
New gene functions in megakaryopoiesis and platelet formation
- C. Gieger, Aparna Radhakrishnan, +160 authors N. Soranzo
- Biology, Medicine
- Nature
- 8 December 2011
Platelets are the second most abundant cell type in blood and are essential for maintaining haemostasis. Their count and volume are tightly controlled within narrow physiological ranges, but there is… Expand