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Rapid NK cell differentiation in a population with near-universal human cytomegalovirus infection is attenuated by NKG2C deletions.
TLDR
These changes coincided with a highly significant drop in anti-HCMV IgG titers by the age of 10 years, suggesting that HCMV infection is brought under control as NK cells differentiate (or vice versa), and lack of expression of NKG2C may be associated with altered control of H CMV in childhood.
High prevalence of natural antibodies against Plasmodium falciparum 83-kilodalton apical membrane antigen (PF83/AMA-1) as detected by capture-enzyme-linked immunosorbent assay using full-length
TLDR
Analysis of populations from villages in Guinea-Bissau and in an area of high malarial transmission in Senegal demonstrated a very high prevalence of naturally acquired serum IgG responses to PF83/AMA-1, showing that PF83-7G8-1 may be a well-recognized asexual parasite antigen.
Innovative and New Approaches to Laboratory Diagnosis of Zika and Dengue: A Meeting Report
TLDR
An international laboratory-response consortium for flaviviruses with a decentralized biobank of well-characterized samples to facilitate assay validation is suggested, and access to proficiency panels are needed to ensure quality control, in additional to in-country capacity building.
Evaluation of a Rapid Diagnostic Test for Yaws Infection in a Community Surveillance Setting
TLDR
Wider access to DPP testing would improve the understanding of worldwide yaws case reporting and the test may play a key role in assessing patients presenting with yaws like lesions in a post-mass drug administration (MDA) setting.
Perceptions, attitudes and practices towards scabies in communities on the Bijagós Islands, Guinea-Bissau
TLDR
Cost played a major role in determining where individuals sought care and both poverty and disease associated stigma resulted in delays seeking care and there is a need to improve community and health care worker education about scabies and improve affordable access to treatment.
Differential frequency of NKG2C/KLRC2 deletion in distinct African populations and susceptibility to Trachoma: a new method for imputation of KLRC2 genotypes from SNP genotyping data
TLDR
The data suggest that NKG2C does not play a major role in trachomatous disease and the new method offers the potential to use SNP arrays from genome wide association studies to study the frequency of KLRC2 deletion in other populations and its association with other diseases.
Aspects of immunity for the AMA-1 family of molecules in humans and non-human primates malarias.
TLDR
The use of an eukaryotic full length recombinant PF83/AMA-1 molecule is described to develop a sensitive ELISA for the determination of serological responses in endemic populations, which reveals surprisingly high levels of humoral response to this quantitatively minor antigen.
Conjunctival Microbiome-Host Responses Are Associated With Impaired Epithelial Cell Health in Both Early and Late Stages of Trachoma
TLDR
Comparisons between active and scarring trachoma supported the relative absence of type-2 interferon responses in scarring, whilst highlighting a common suppression of re-epithelialization with altered epithelial and bacterial adhesion, likely contributing to development of scarring pathology.
The prevalence of scabies, pyoderma and other communicable dermatoses in the Bijagos Archipelago, Guinea-Bissau
TLDR
A cross-sectional population-based skin-surveys of children in the Bijagós Archipelago of Guinea-Bissau during the dry season and wet season demonstrates the substantial disease burden caused by common communicable dermatoses in this setting.
The prevalence of scabies, pyoderma and other communicable dermatoses in the Bijagos Archipelago, Guinea-Bissau
TLDR
There is a need to consider common dermatoses as part of Universal Health Coverage to deliver skin-health for all in Guinea-Bissau, and the substantial disease burden caused by common communicable dermatoses in this setting is demonstrated.
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