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The Mechanism of Excessive Intestinal Inflammation in Necrotizing Enterocolitis: An Immature Innate Immune Response
TLDR
It is concluded that the excessive inflammatory response of the immature intestine, a hallmark of NEC, is due to a developmental immaturity in innate immune response genes.
BMP signaling is necessary for neural crest cell migration and ganglion formation in the enteric nervous system
TLDR
An essential role for BMP signaling in these aspects of ENS development is supported and provides a basis for further investigation of these proteins in the etiology of neuro-intestinal disorders.
Endothelin-3 regulates neural crest cell proliferation and differentiation in the hindgut enteric nervous system.
TLDR
Multiple roles for ET3 signaling during ENS development in the avian hindgut are demonstrated, where it influences NCC proliferation, differentiation, and migration.
Genetic Steps to Organ Laterality in Zebrafish
TLDR
A genetic screen to discover mutations which perturb organ laterality is reported, finding that visceral organ positions are predicted by the direction of the preceding cardiac jog, and that laterality decisions of organs may be independently perturbed.
Building a brain in the gut: development of the enteric nervous system
TLDR
This review focuses on the molecular and genetic factors regulating ENS development from NCC, the clinical genetics of HSCR and its associated syndromes, and recent advances aimed at improving the understanding and treatment of enteric neuropathies.
Endothelial cells promote migration and proliferation of enteric neural crest cells via beta1 integrin signaling.
TLDR
ECs provide a substrate for the migration of ENCCs via an interaction between beta1 integrins on the ENCC surface and extracellular matrix proteins expressed by the intestinal vasculature, which may play an important role in guiding migration and patterning in the developing ENS.
Analysis of gastrointestinal physiology using a novel intestinal transit assay in zebrafish
TLDR
A method for visualizing intestinal transit, the physiological result of peristaltic contractions, in larval zebrafish is developed, which allows direct, non‐invasive observation of luminal content as it traverses the gut.
Late complications of newborn circumcision: a common and avoidable problem
TLDR
The results indicate the need to undertake a collaborative study to define the incidence of complications following newborn circumcisions, which should be performed by practitioners with adequate training in the technique of their choice and its post-operative care.
Enteric nervous system development: A crest cell's journey from neural tube to colon.
TLDR
This review summarizes the current understanding of the factors involved in early development of the ENS and discusses areas in need of further investigation.
Bone morphogenetic protein signaling pathway plays multiple roles during gastrointestinal tract development
TLDR
It is demonstrated that BMP signaling is activated in all the tissue layers of the GI tract during the development and plays a role during interactions and reciprocal communications of these tissue layers.
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