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BRAF gene duplication constitutes a mechanism of MAPK pathway activation in low-grade astrocytomas.
TLDR
Both the stable silencing of BRAF through shRNA lentiviral transduction and pharmacological inhibition of MEK1/2, the immediate downstream phosphorylation target of BRAf, blocked the proliferation and arrested the growth of cultured tumor cells derived from low-grade gliomas and suggest inhibition of the MAPK pathway as a potential treatment.
DNA methylation-based classification of central nervous system tumours
TLDR
This work presents a comprehensive approach for the DNA methylation-based classification of central nervous system tumours across all entities and age groups, and shows that the availability of this method may have a substantial impact on diagnostic precision compared to standard methods.
Oncogenic FAM131B–BRAF fusion resulting from 7q34 deletion comprises an alternative mechanism of MAPK pathway activation in pilocytic astrocytoma
TLDR
The findings of this study further underline the fundamental role of RAF kinase fusion products as a tumor-specific marker and an ideally suited drug target for PA.
Long-term follow-up of the multicenter, multidisciplinary treatment study HIT-LGG-1996 for low-grade glioma in children and adolescents of the German Speaking Society of Pediatric Oncology and
TLDR
Diencephalic syndrome and incomplete resection were found to be unfavorable factors for OS and EFS, age ≥11 years for OS, and supratentorial midline location for EFS.
Low grade chiasmatic-hypothalamic glioma-carboplatin and vincristin chemotherapy effectively defers radiotherapy within a comprehensive treatment strategy -- report from the multicenter treatment
TLDR
Within the comprehensive treatment strategy for low grade glioma HIT-LGG 1996 chemotherapy is effective to delay the need for early radiotherapy in chiasmatic-hypothalamicglioma children with an age at diagnosis < 1 year and non-pilocytic histology are at increased risk for early progression.
Prospective randomised trial of chemotherapy given before radiotherapy in childhood medulloblastoma. International Society of Paediatric Oncology (SIOP) and the (German) Society of Paediatric
TLDR
A negative interaction was observed between the receipt of the chemotherapy and reduced dose radio-therapy with a particularly poor outcome being observed in this group of children.
Thalamic high-grade gliomas in children: a distinct clinical subset?
TLDR
Thalamic HGG appeared to represent a clinically distinct subgroup of pediatric HGG, and the varying extent of tumor resection in the different tumor localizations may play some role in the observed clinical differences, as shown by multivariate Cox regression analyses.
Intensive chemotherapy improves survival in pediatric high‐grade glioma after gross total resection: results of the HIT‐GBM‐C protocol
The authors hypothesized that intensified chemotherapy in protocol HIT‐GBM‐C would increase survival of pediatric patients with high‐grade glioma (HGG) and diffuse intrinsic pontine glioma (DIPG).
Localized infant neuroblastomas often show spontaneous regression: results of the prospective trials NB95-S and NB97.
TLDR
Spontaneous regression is regularly seen in infants with localized neuroblastoma and is not limited to the first year of life, and a wait-and-see strategy is justified in those patients.
Treatment options in childhood pontine gliomas
TLDR
Irradiation is an effective element for the treatment of pontine gliomas and intensive chemotherapy seems to be important in achieving a better OS.
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