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The P2X7 Receptor in Infection and Inflammation
The central role played by the P2X7 receptor in promoting inflammation and driving innate and adaptive immunity is discussed, with an in‐depth knowledge of its structure and of the associated signal transduction mechanisms needed for an effective therapeutic development. Expand
Expression of P2X7 receptor increases in vivo tumor growth.
It is found that P2X7 exhibits significant growth-promoting effects in vivo, and immunohistochemistry revealed strong P2x7 positivity in several human cancers. Expand
The P2X7 receptor: A main player in inflammation
- E. Adinolfi, A. Giuliani, Elena De Marchi, A. Pegoraro, Elisa Orioli, F. Di Virgilio
- Biology, Medicine
- Biochemical pharmacology
- 1 December 2017
The numerous intracellular pathways related to inflammation and activated by the P2X7R are described, including the NLRP3 inflammasome, NF‐kB, NFAT, GSK3&bgr; and VEGF, and the involvement of P2x7R in chronic diseases is discussed. Expand
P2 receptors and extracellular ATP: a novel homeostatic pathway in inflammation.
The purinergic signalling system is bound to yield novel therapeutic opportunities for the treatment of inflammatory diseases because it is comprised of extracellular ATP, P2 receptors and ecto-enzyme cascades. Expand
Extracellular nucleotides and nucleosides as signalling molecules.
These processes confer a remarkable level of selectivity and plasticity to purinergic signalling that makes this network one of the most relevant extracellular messenger systems in higher organisms. Expand
Accelerated tumor progression in mice lacking the ATP receptor P2X7.
Results showed that host P2X7R expression was critical to support an antitumor immune response, and to restrict tumor growth and metastatic diffusion. Expand
The P2X7 Receptor-Interleukin-1 Liaison
Evidence supporting the key role of the P2X7R in IL-1β production is summarized, with special emphasis on the mechanism of release, a process that is still a matter of controversy. Expand
Trophic Activity of Human P2X7 Receptor Isoforms A and B in Osteosarcoma
The data show that the majority of human osteosarcomas express P2X7RA and B and suggest that expression of either isoform is differently coupled to cell growth or activity. Expand
Effect of the combined treatment with 5-fluorouracil, gamma-interferon or folinic acid on carcinoembryonic antigen expression in colon cancer cells.
- A. Aquino, S. Prete, +7 authors L. De Vecchis
- Biology, Medicine
- Clinical cancer research : an official journal of…
- 1 October 1998
In vivo studies showed, for the first time, that 5-FU, alone or combined with gamma-IFN, increases the amount of CEA protein over controls, either in cancer cells or in peripheral blood of nude mice bearing HT-29 cells. Expand
Non-nucleotide Agonists Triggering P2X7 Receptor Activation and Pore Formation
- F. Di Virgilio, A. Giuliani, Valentina Vultaggio-Poma, S. Falzoni, A. Sarti
- Chemistry, Medicine
- Front. Pharmacol.
- 1 February 2018
Solid data show that NAD+ covalently modifies the P2X7R of mouse T lymphocytes, thus lowering the ATP threshold for activation, and raises the intriguing question of how these different non-nucleotide ligands may co-operate with ATP at inflammatory or tumor sites. Expand