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The P2X7 Receptor in Infection and Inflammation
- F. Di Virgilio, Diego Dal Ben, A. C. Sarti, A. Giuliani, S. Falzoni
- Medicine, Biology
- 18 July 2017
&NA; Adenosine triphosphate (ATP) accumulates at sites of tissue injury and inflammation. Effects of extracellular ATP are mediated by plasma membrane receptors named P2 receptors (P2Rs). The P2R… Expand
Expression of P2X7 receptor increases in vivo tumor growth.
The P2X7 receptor is an ATP-gated ion channel known for its cytotoxic activity. However, recent evidence suggests a role for P2X7 in cell proliferation. Here, we found that P2X7 exhibits significant… Expand
P2 receptors and extracellular ATP: a novel homeostatic pathway in inflammation.
Inflammation is an important homeostatic response, which is managed by a complex network of interrelated pathways that determine the level, intensity and localization of inflammation. We now know… Expand
The P2X7 receptor: A main player in inflammation
- E. Adinolfi, A. Giuliani, E. De Marchi, Anna Pegoraro, E. Orioli, F. Di Virgilio
- Medicine, Chemistry
- Biochemical pharmacology
- 1 December 2017
&NA; Damage associated molecular patterns (DAMPs) are intracellular molecules released from infected or injured cells to activate inflammatory and reparatory responses. One of the most ancient and… Expand
The P2X7 Receptor-Interleukin-1 Liaison
Interleukin-1β (IL-1β) plays a central role in stimulation of innate immune system and inflammation and in several chronic inflammatory diseases. These include rare hereditary conditions, e.g.,… Expand
Trophic Activity of Human P2X7 Receptor Isoforms A and B in Osteosarcoma
The P2X7 receptor (P2X7R) is attracting increasing attention for its involvement in cancer. Several recent studies have shown a crucial role of P2X7R in tumour cell growth, angiogenesis and… Expand
Extracellular nucleotides and nucleosides as signalling molecules.
Extracellular nucleotides, mainly ATP, but also ADP, UTP, UDP and UDP-sugars, adenosine, and adenine base participate in the "purinergic signalling" pathway, an ubiquitous system of cell-to-cell… Expand
P2X7 Receptor Function in Bone-Related Cancer
Modulation of tumor microenvironment by different mediators is central in determining neoplastic formation and progression. Among these molecules extracellular ATP is emerging as a good candidate in… Expand
P2×7 targeting inhibits growth of human mesothelioma
Malignant pleural mesothelioma (MPM) is an aggressive tumor refractory to anti-blastic therapy. MPM cells show several genetic and biochemical defects, e.g. overexpression of oncogenes,… Expand
Changes in murine bone marrow macrophages and erythroid burst‐forming cells following the intravenous injection of liposome‐encapsulated dichloromethylene diphosphonate (Cl2MDP)
- A. Giuliani, E. Wiener, M. J. Lee, I. N. Brown, G. Berti, S. N. Wickramasinghe
- European journal of haematology
- 1 April 2001
Abstract: In order to explore the effect on bone marrow macrophages of liposome‐encapsulated dichloromethylene diphosphonate (Cl2MDP), mice were injected intravenously with a preparation of such… Expand