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The P2X7 Receptor in Infection and Inflammation
&NA; Adenosine triphosphate (ATP) accumulates at sites of tissue injury and inflammation. Effects of extracellular ATP are mediated by plasma membrane receptors named P2 receptors (P2Rs). The P2RExpand
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Expression of P2X7 receptor increases in vivo tumor growth.
The P2X7 receptor is an ATP-gated ion channel known for its cytotoxic activity. However, recent evidence suggests a role for P2X7 in cell proliferation. Here, we found that P2X7 exhibits significantExpand
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P2 receptors and extracellular ATP: a novel homeostatic pathway in inflammation.
Inflammation is an important homeostatic response, which is managed by a complex network of interrelated pathways that determine the level, intensity and localization of inflammation. We now knowExpand
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The P2X7 receptor: A main player in inflammation
&NA; Damage associated molecular patterns (DAMPs) are intracellular molecules released from infected or injured cells to activate inflammatory and reparatory responses. One of the most ancient andExpand
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The P2X7 Receptor-Interleukin-1 Liaison
Interleukin-1β (IL-1β) plays a central role in stimulation of innate immune system and inflammation and in several chronic inflammatory diseases. These include rare hereditary conditions, e.g.,Expand
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Trophic Activity of Human P2X7 Receptor Isoforms A and B in Osteosarcoma
The P2X7 receptor (P2X7R) is attracting increasing attention for its involvement in cancer. Several recent studies have shown a crucial role of P2X7R in tumour cell growth, angiogenesis andExpand
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Extracellular nucleotides and nucleosides as signalling molecules.
Extracellular nucleotides, mainly ATP, but also ADP, UTP, UDP and UDP-sugars, adenosine, and adenine base participate in the "purinergic signalling" pathway, an ubiquitous system of cell-to-cellExpand
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P2X7 Receptor Function in Bone-Related Cancer
Modulation of tumor microenvironment by different mediators is central in determining neoplastic formation and progression. Among these molecules extracellular ATP is emerging as a good candidate inExpand
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P2×7 targeting inhibits growth of human mesothelioma
Malignant pleural mesothelioma (MPM) is an aggressive tumor refractory to anti-blastic therapy. MPM cells show several genetic and biochemical defects, e.g. overexpression of oncogenes,Expand
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Changes in murine bone marrow macrophages and erythroid burst‐forming cells following the intravenous injection of liposome‐encapsulated dichloromethylene diphosphonate (Cl2MDP)
Abstract: In order to explore the effect on bone marrow macrophages of liposome‐encapsulated dichloromethylene diphosphonate (Cl2MDP), mice were injected intravenously with a preparation of suchExpand
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