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  • Influence
N-Acylethanolamines in human reproductive fluids.
N-Acylethanolamines (NAEs) are an important family of lipid-signaling molecules. Arachidonylethanolamide (anandamide) (AEA), palmitoylethanolamide (PEA), and oleoylethanolamide (OEA) are co-producedExpand
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Mechanisms of endocannabinoid inactivation: biochemistry and pharmacology.
The endocannabinoids, a family of endogenous lipids that activate cannabinoid receptors, are released from cells in a stimulus-dependent manner by cleavage of membrane lipid precursors. AfterExpand
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  • Open Access
The endocannabinoid system as a target for therapeutic drugs.
Cannabinoid receptors, the molecular targets of the cannabis constituent Delta9-tetrahydrocannabinol, are present throughout the body and are normally bound by a family of endogenous lipids - theExpand
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Evidence that anandamide‐signaling regulates human sperm functions required for fertilization
Ejaculated mammalian sperm require several hours exposure to secretions in female reproductive tracts, or incubation in appropriate culture medium in vitro, before acquiring the capacity to fertilizeExpand
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Quantification of endocannabinoids in rat biological samples by GC/MS: technical and theoretical considerations.
In the last several years, interest has increased significantly about the endocannabinoids anandamide and 2-arachidonylglycerol, two lipid messengers that activate cannabinoid receptors.Expand
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Quantification of bioactive acylethanolamides in rat plasma by electrospray mass spectrometry.
We developed a high-performance liquid chromatography/mass spectrometry (HPLC/MS) method for the identification and quantification of anandamide, an endogenous cannabinoid substance, and other fattyExpand
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Elevated circulating levels of anandamide after administration of the transport inhibitor, AM404.
The biological actions of the endogenous cannabinoid anandamide are terminated by carrier-mediated transport into neurons and astrocytes, followed by enzymatic hydrolysis. Anandamide transport isExpand
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Isotope dilution GC/MS determination of anandamide and other fatty acylethanolamides in rat blood plasma
Anandamide and allied fatty acylethanolamides (AEs) may act as signalling molecules in brain and peripheral tissues. In the present study, we describe an electron‐impact gas chromatography/massExpand
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  • Open Access
Release of Fatty Acid Amides in a Patient With Hemispheric Stroke: A Microdialysis Study
Background— Excitotoxic insults such as stroke may induce release of fatty acid ethanolamides (FAEs), contributing to the downstream events in the ischemic cascade. We therefore studied release ofExpand
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Engineering a Stable and Selective Peptide Blocker of the Kv1.3 Channel in T Lymphocytes
Kv1.3 potassium channels maintain the membrane potential of effector memory (TEM) T cells that are important mediators of multiple sclerosis, type 1 diabetes mellitus, and rheumatoid arthritis. TheExpand
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