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Studies on the antihypertensive, antispasmodic, bronchodilator and hepatoprotective activities of the Carum copticum seed extract.
The results indicate the presence of calcium antagonist(s) in Carum copticum seeds and thus provides sound mechanistic basis for some of their folkloric uses.
Effects of flavonoids on vascular smooth muscle of the isolated rat thoracic aorta.
The relaxant effects of most of the flavonoids involve in part the release of nitric oxide and prostaglandins from the endothelium as pretreatment with L-NAME and indomethacin attenuated the responses.
Isolation and structure elucidation of new nitrile and mustard oil glycosides from Moringa oleifera and their effect on blood pressure.
This is the first report of the isolation of nitriles, an isothiocyanate, and thiocarbamates from the same plant species.
Critical evaluation of the claims made by pharmaceutical companies in drug promotional material in Pakistan.
Since GPs in Pakistan rate pharmaceutical companies as their primary source of information regarding drugs, it can be anticipated that inappropriate advertisement claims would lead to irrational prescribing if physicians had no any other information to follow.
Inhibitory effect of curcuminoids on acetylcholinesterase activity and attenuation of scopolamine-induced amnesia may explain medicinal use of turmeric in Alzheimer's disease
  • T. Ahmed, A. Gilani
  • Chemistry, Medicine
    Pharmacology Biochemistry and Behavior
  • 1 February 2009
Data indicate that curcuminoids and all individual components exceptCurcumin possess pronounced AChE inhibitory activity, which might possess better therapeutic profile than curCumin for its medicinal use in AD.
Inhibitory effect of curcumin, a food spice from turmeric, on platelet-activating factor- and arachidonic acid-mediated platelet aggregation through inhibition of thromboxane formation and Ca2+
The results suggest that the curcumin-mediated preferential inhibition of PAF- and AA-induced platelet aggregation involves inhibitory effects on TXA2 synthesis and Ca2+ signaling, but without the involvement of PKC.
Citrullus colocynthis (L.) Schrad (bitter apple fruit): a review of its phytochemistry, pharmacology, traditional uses and nutritional potential.
It is evident from the literature that Citrullus colocynthis possesses a wide range of medicinal uses and has been well studied for its antidiabetic, anticancer, antioxidant, antimicrobial and anti-inflammatory activities, while its therapeutic potential for gut, airways and cardiovascular disorders remains to be explored.
Quality of pharmacies in Pakistan: a cross-sectional survey.
Most drug sellers had fragmentary knowledge regarding drug dispensing and storage, and improper dispensing practices and there is a need to enforce existing legislation with training programmes directed towards drug sellers and to involve the pharmaceutical industry, which plays an important role in influencing pharmacy knowledge and practices.
Berberine and neurodegeneration: A review of literature.
The main objective of this review is to discuss the role of oxidative stress in neurodegeneration and the potential role of antioxidant compounds, in particular Berberine which is analyzed in its chemical structure, source, bioavailability, therapeutic potential, with special attention to its mechanism of action at a molecular level.
Hypotensive constituents from the pods of Moringa oleifera.
Two new compounds, O-[2'-hydroxy-3'-(2"-heptenyloxy)]-propyl undecanoate and O-ethyl-4-[(alpha-L-rhamnosyloxy)-benzyl] carbamate along with the known substances methyl p-hydroxybenzoate and beta-sitosterol have also been isolated and showed promising hypotensive activity.