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Novel molecular profiles of endometrial cancer—new light through old windows
Endometrial carcinoma (EC) is the most common gynecological malignancy in the western world. A widely accepted dualistic model, which has been established on a morphological basis, differentiates ECExpand
The EMT signaling pathways in endometrial carcinoma
The most common hallmarks of EMT have been found in EC, either at the level of E-cadherin loss or at the induction of its repressors, as well as other molecular alterations consistent with the mesenchymal phenotype-like L1CAM and BMI-1 up-regulation. Expand
Molecular bases of endometrial cancer: New roles for new actors in the diagnosis and the therapy of the disease
The need to explore new potential biomarkers of EC as a tool for the detection and monitoring of aggressive endometrial tumors will allow us to develop novel and more selective molecular targeted therapies against EC. Expand
Molecular profiling of circulating tumor cells links plasticity to the metastatic process in endometrial cancer
The CTC-phenotype found in endometrial CTC was recapitulated by over-expressing ETV5 in the EC cell line Hec1A and demonstrated an advantage in the promotion of metastasis in an in vivo mouse model of CTC dissemination and homing. Expand
Exosome-like vesicles in uterine aspirates: a comparison of ultracentrifugation-based isolation protocols
The Standard protocol was the best performing procedure since the other two tested protocols did not ameliorate neither yield nor purity of exosome-like vesicles, and contributes to establishing the basis for future comparative studies to foster the field of biomarker research in gynecology. Expand
L1CAM expression in endometrial carcinomas: an ENITEC collaboration study
The expression of L1CAM is a strong predictor of poor outcome in EECs, but not NEECs; it is strongly associated with non-endometrioid histology and distant spread, and could improve the postoperative selection of high-risk endometrial carcinomas. Expand
High-Risk Endometrial Carcinoma Profiling Identifies TGF-β1 as a Key Factor in the Initiation of Tumor Invasion
It is shown that the characterization of the molecular changes associated with the acquisition of an aggressive phenotype represents a realistic strategy for the rational identification and characterization of new potential therapeutic targets in an effort to improve the clinical management and the outcome of high-risk endometrial cancer patients. Expand
Endometrial cancer in polyps: a clinical study of 27 cases.
Postmenopausal women with endometrial polyps diagnosed by ultrasonography should undergo directed biopsies under hysteroscopic vision, as the present series confirms the good prognosis ofendometrial cancer in polyps. Expand
Total laparoscopic radical hysterectomy with intraoperative sentinel node identification in patients with early invasive cervical cancer.
This study shows the feasibility of the combination of laparoscopy intraoperative sentinel node mapping and laparoscopic radical surgery in the context of minimally invasive surgery for the management of patients with early cervical cancer. Expand
Intraoperative sentinel node identification in early stage cervical cancer using a combination of radiolabeled albumin injection and isosulfan blue dye injection.
Sentinel lymph node identification with technetium-99m-labeled nanocolloid combined with blue dye injection is feasible and showed a 100% negative predictive value, and potentially identified women in whom lymph node dissection can be avoided. Expand