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CYFIP/Sra-1 Controls Neuronal Connectivity in Drosophila and Links the Rac1 GTPase Pathway to the Fragile X Protein
Neuronal plasticity requires actin cytoskeleton remodeling and local protein translation in response to extracellular signals. Rho GTPase pathways control actin reorganization, while the fragile XExpand
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Glide directs glial fate commitment and cell fate switch between neurones and glia.
Glial cells constitute the second component of the nervous system and are important during neuronal development. In this paper we describe a gene, glial cell deficient, (glide), that is necessary forExpand
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Glide2, a second glial promoting factor in Drosophila melanogaster
The fly glial cell deficient/glial cell missing (glide/gcm) gene codes for a transcription factor that induces gliogenesis. Lack of its product eliminates lateral glial cells in the embryonic nervousExpand
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glide/gcm is expressed and required in the scavenger cell lineage.
Glial cell differentiation in Drosophila melanogaster requires the activity of glide/gcm (glial cell deficient/glial cell missing). The role of this gene is to direct the cell fate switch betweenExpand
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Multipotent neural stem cells generate glial cells of the central complex through transit amplifying intermediate progenitors in Drosophila brain development.
The neural stem cells that give rise to the neural lineages of the brain can generate their progeny directly or through transit amplifying intermediate neural progenitor cells (INPs). TheExpand
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Glial differentiation does not require a neural ground state.
Glial cells differentiate from the neuroepithelium. In flies, gliogenesis depends on the expression of glial cell deficient/glial cell missing (glide/gcm). The phenotype of glide/gcm loss- andExpand
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Positive autoregulation of the glial promoting factor glide/gcm
Fly gliogenesis depends on the glial‐cell‐deficient/glial‐cell‐missing (glide/gcm) transcription factor. glide/gcm expression is necessary and sufficient to induce the glial fate within and outsideExpand
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Predetermined embryonic glial cells form the distinct glial sheaths of the Drosophila peripheral nervous system
One of the numerous functions of glial cells in Drosophila is the ensheathment of neurons to isolate them from the potassium-rich haemolymph, thereby establishing the blood-brain barrier. PeripheralExpand
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WAVE/SCAR, a multifunctional complex coordinating different aspects of neuronal connectivity.
Although it is well established that the WAVE/SCAR complex transduces Rac1 signaling to trigger Arp2/3-dependent actin nucleation, regulatory mechanisms of this complex and its versatile function inExpand
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DPP signaling controls development of the lamina glia required for retinal axon targeting in the visual system of Drosophila
The Drosophila visual system consists of the compound eyes and the optic ganglia in the brain. Among the eight photoreceptor (R) neurons, axons from the R1-R6 neurons stop between two layers of glialExpand
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