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Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis
TLDR
Moderate powered genome-wide association studies (GWAS) have enabled more than 20 additional risk loci to be identified and have shown that multiple variants exerting modest individual effects have a key role in disease susceptibility.
International Pediatric Multiple Sclerosis Study Group criteria for pediatric multiple sclerosis and immune-mediated central nervous system demyelinating disorders: revisions to the 2007 definitions
TLDR
Revised criteria are proposed for pediatric acute disseminated encephalomyelitis, pediatric clinically isolated syndrome, pediatric neuromyELitis optica and pediatric MS to incorporate advances in delineating the clinical and neuroradiologic features of these disorders.
Multiple sclerosis in childhood: clinical features of 149 cases
TLDR
In early onset MS patients with disease duration < 8 years, cases with EDSS > 6 were slightly more frequent than in the AOMS group and the frequency of cases for different levels of disability was similar for disease duration > 8 years.
The prevalence of pain in multiple sclerosis
TLDR
Comparison between different groups showed significant differences for age, Expanded Disability Status Scale, disease duration, and disease course, but not for sex, underlines the relevance of pain in the clinical history of MS.
Evidence of early cortical atrophy in MS
TLDR
The extent of the changes suggests that neocortical GM pathology may occur early in the course of the disease in both RR and PP MS patients and contribute significantly to neurologic impairment.
In vivo assessment of cervical cord damage in MS patients: a longitudinal diffusion tensor MRI study.
TLDR
This study shows that both progressive tissue loss and injury to the remaining tissue occur in the cervical cord of MS patients, and that these two components of cord damage are not strictly interrelated, thus suggesting that a multiparametric MRI approach is needed to achieve more accurate estimates of such a damage.
Cognitive and psychosocial features of childhood and juvenile MS
TLDR
In childhood and juvenile cases, multiple sclerosis is associated with cognitive impairment and low IQ scores, the latter related to younger age at onset, which is of critical importance in helping children and adolescents with MS to manage their difficulties and psychosocial challenges.
Validation of Italian multiple sclerosis quality of life 54 questionnaire
TLDR
The Italian version of MSQOL-54 is easy to administer and is well accepted by patients, and multiple linear regression modelling showed that age and BDI independently predicted physical health composite and mental health composite, while age and depressive symptoms has a major influence.
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