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Potential application of gaseous nitric oxide as a topical antimicrobial agent.
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14-3-3σ associates with cell surface aminopeptidase N in the regulation of matrix metalloproteinase-1
TLDR
Evidence is provided that APN is a novel cell surface receptor for stratifin and a potential target in the regulation of MMP-1 expression in epithelial–stromal cell communication.
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Role of keratinocyte–fibroblast cross‐talk in development of hypertrophic scar
TLDR
This review addresses the question of how keratinocyte–fibroblast interaction plays a role in controlling the expression of key extracellular matrix molecules such as matrix metalloproteinases, which are critical in the healing process following any types of insults to the skin.
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COVID-19 Serological Tests: How Well Do They Actually Perform?
TLDR
Significant variability in the accuracy of marketed tests is found and several lab-based and point-of-care rapid serological tests with high levels of performance are highlighted, highlighting the need for ongoing independent evaluations of commercialized COVID-19 diagnostic tests.
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The role of stratifin in fibroblast–keratinocyte interaction
TLDR
The MMP profile induced by stratifin is an interesting starting point to establish new therapeutic tools to control the process of wound healing and this review will focus on site of synthesis and mode of action of strat ifin in skin and wound healing.
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A novel role for ezrin in breast cancer angio/lymphangiogenesis
TLDR
A novel function for ezrin is described in the regulation of tumour-induced angio/lymphangiogenesis promoted by Src in breast cancer, which might prove to be a beneficial prognostic/predictive biomarker for early-stage metastatic breast cancer.
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A LATS biosensor screen identifies VEGFR as a regulator of the Hippo pathway in angiogenesis
TLDR
A bioluminescence-based biosensor is developed that monitors the activity of the Hippo core component LATS kinase and identifies VEGF signalling as an upstream regulator of LATS, supporting a role for Hippo signalling during angiogenesis.
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STING agonist therapy in combination with PD-1 immune checkpoint blockade enhances response to carboplatin chemotherapy in high-grade serous ovarian cancer
TLDR
Findings will enable rational design of clinical trials aimed at combinatorial approaches to improve chemotherapy response and survival in HGSC patients and help to understand the drivers of tumours from chemoresistant patients.
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Local expression of indoleamine 2,3-dioxygenase protects engraftment of xenogeneic skin substitute.
TLDR
Findings suggest that IDO may have an application in promoting the engraftment of skin substitutes and other transplanted organs after being confirmed that it can induce angiogenesis through the depletion of tryptophan.
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Keratinocyte-conditioned media regulate collagen expression in dermal fibroblasts.
TLDR
Results provide further evidence that type I collagen expression and synthesis in fibroblasts are regulated by a keratinocyte-releasable factor(s) with an apparent molecular weight between 30 and 50 kDa.
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