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Human Anti-Inflammatory Macrophages Induce Foxp3+GITR+CD25+ Regulatory T Cells, Which Suppress via Membrane-Bound TGFβ-11
TLDR
Mφ2 cells are identified as a novel APC subset capable of inducing Tregs and have important implications for understanding Treg dynamics in pathological conditions where macrophages play a key role in inflammatory disease control and exacerbation. Expand
Intracellular bacterial growth is controlled by a kinase network around PKB/AKT1
TLDR
Using a reciprocal chemical genetics approach, kinase inhibitors with antibiotic properties and their host targets are identified, and host signalling networks that are activated by intracellular bacteria for survival are determined. Expand
Antigenic Equivalence of Human T-Cell Responses toMycobacterium tuberculosis-Specific RD1-Encoded Protein Antigens ESAT-6 and Culture Filtrate Protein 10 and to Mixtures of Synthetic Peptides
TLDR
Results show that mixtures of synthetic overlapping peptide mixtures have potency equivalent to that of whole ESAT-6 and CFP-10 for sensitive and specific detection of infection with M. tuberculosis, and peptides have the advantage of faster production at lower cost. Expand
HLA-DR binding analysis of peptides from islet antigens in IDDM.
TLDR
A strong correlation between antigenicity and HLA-DR binding affinity of GAD65 peptides in IDDM is indicated, which suggests that the absence of insulin-reactive T-cells in DR2+ individuals may be explained by negative selection on high-affinity DR2 binding insulin peptides. Expand
HLA-DR3 molecules can bind peptides carrying two alternative specific submotifs.
TLDR
It is found that the requirements for binding to HLA-DR3 vary among different DR3 binding peptides; the absence of an anchor or the presence of only a weak anchor residue at either position n or n + 3 can be compensated for by the existence of a strong, positively charged anchor residues at position n + 5. Expand
Identification of a human CD8+ regulatory T cell subset that mediates suppression through the chemokine CC chemokine ligand 4
TLDR
A human CD8+lymphocyte activation gene-3 (LAG-3)+CD25+FoxP3+ Treg subset, which suppresses T cells partly through the secretion of CC chemokine ligand 4 (CCL4), which can inhibit T cell activation by interfering with T cell receptor signaling, may play a role in immunoregulation in humans, including infectious diseases. Expand
Identification of Major Epitopes of Mycobacterium tuberculosis AG85B That Are Recognized by HLA-A*0201-Restricted CD8+ T Cells in HLA-Transgenic Mice and Humans1
TLDR
The results demonstrate the presence of HLA class I-restricted CD8+ CTL against a major Ag of M. tuberculosis in HLA-A2/Kb transgenic mice and humans and identify Ag85B epitopes that are strongly recognized by HLA*0201-restrictedCD8+ T cells in humans and mice and represent potential subunit components for the design of vaccines against tuberculosis. Expand
Frequent detection of human papillomavirus 16 E2-specific T-helper immunity in healthy subjects.
TLDR
The data are the first to reveal that the T-cell repertoire of healthy donors can contain particularly high frequencies of E2-specific memory Th cells and suggest that boosting of this immunity can be used for preventive and therapeutic vaccination against HPV-induced lesions. Expand
Mycobacterium tuberculosis Peptides Presented by HLA-E Molecules Are Targets for Human CD8+ T-Cells with Cytotoxic as well as Regulatory Activity
TLDR
The results significantly increase the understanding of the human immune response to Mtb by identification of CD8+ T-cell responses to novel HLA-E binding peptides of Mtb, which have cytotoxic as well as immunoregulatory activity. Expand
Regulation of Mycobacterial Heat‐Shock Protein‐Reactive T Cells by HLA Class II Molecules: Lessons from Leprosy
TLDR
A human disease where (HLA) class II genes play an important role is leprosy, the chronic infectious disease caused by Mycobacterium leprae, and HLA class II gene products might regulate these responses by restricting and regulating T-helper cell activity against M. lepRAe. Expand
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