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Upstream Open Reading Frames as Regulators of mRNA Translation
  • David R. Morris, A. Geballe
  • Medicine, Biology
  • Molecular and Cellular Biology
  • 1 December 2000
Some of the general principles by which uORFs participate in translational control are beginning to be understood are reviewed, which include the process of recognition of uORs, regulation of reinitiation at downstream cistrons after translation of u ORFs, and regulatory effects of peptides encoded by uORF. Expand
Functional Analysis of the Human Cytomegalovirus US28 Gene by Insertion Mutagenesis with the Green Fluorescent Protein Gene
The ability of the US28 gene to bind chemokines was shown to cause a significant reduction in the concentration of RANTES in the medium of infected cells, demonstrating that US28 is responsible for the β-chemokine binding and induced calcium signaling in HCMV-infected cells. Expand
Protein kinase R reveals an evolutionary model for defeating viral mimicry
Host factors such as PKR can compete in molecular ‘arms races’ with mimics because of evolutionary flexibility at protein interaction interfaces challenged by mimicry, uncovering evolutionary strategies by which host proteins can overcome mimicry. Expand
Initiation codons within 5'-leaders of mRNAs as regulators of translation.
Why should a preponderance of proto-oncogenes, growth factor genes and growth factor receptor genes contain translation initiation codons and associated open reading frames in their 5'-leaders? AnExpand
The AIM2-like Receptors Are Dispensable for the Interferon Response to Intracellular DNA.
It is found that AIM2-like receptors are dispensable for the type I interferon (IFN) response to transfected DNA ligands, DNA virus infection, and lentivirus infection and do not contribute to autoimmune disease in the Trex1(-/-) mouse model of Aicardi-Goutières Syndrome. Expand
Cytomegalovirus: pathogen, paradigm, and puzzle.
Recent advances that are reshaping the view and approach to CMV are reviewed, including the mechanisms of persistence and pathogenesis and its hypothesized roles in a variety of human illnesses. Expand
Cofactor requirement for human immunodeficiency virus type 1 entry into a CD4-expressing human cell line
Results suggest that HeLa cells express a factor(s) that can complement the viral entry defect of U373-CD4 cells and is necessary for efficient CD4-mediated HIV-1 infection. Expand
Sequence requirements for activation of the HIV-1 LTR by human cytomegalovirus.
It is demonstrated that more than one nonoverlapping region of the HIV-1 promoter is capable of responding to CMV, and it is shown that in addition to immediate early region 2, immediateEarly region 1 is able to activate HIV- 1 LTR-directed gene expression. Expand
The Human Cytomegalovirus Protein TRS1 Inhibits Autophagy via Its Interaction with Beclin 1
It is shown that the HCMV TRS1 protein blocks autophagosome biogenesis and that a T RS1 deletion mutant is defective in autophagy inhibition, and it is demonstrated that the Beclin 1-binding domain of TRS 1 is essential to inhibit autophophagy. Expand
Evasion of Cellular Antiviral Responses by Human Cytomegalovirus TRS1 and IRS1
Results demonstrate that TRS1 and IRS1 are able to counteract critical host cell antiviral response pathways. Expand