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Genomic expression programs in the response of yeast cells to environmental changes.
We explored genomic expression patterns in the yeast Saccharomyces cerevisiae responding to diverse environmental transitions. DNA microarrays were used to measure changes in transcript levels overExpand
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Genomic expression responses to DNA-damaging agents and the regulatory role of the yeast ATR homolog Mec1p.
Eukaryotic cells respond to DNA damage by arresting the cell cycle and modulating gene expression to ensure efficient DNA repair. The human ATR kinase and its homolog in yeast, MEC1, play centralExpand
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Genome-wide Analysis of Gene Expression Regulated by the Calcineurin/Crz1p Signaling Pathway in Saccharomyces cerevisiae *
In Saccharomyces cerevisiae, the Ca2+/calmodulin-dependent protein phosphatase, calcineurin, is activated by specific environmental conditions, including exposure to Ca2+ and Na+, and induces geneExpand
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Exploring the conditional coregulation of yeast gene expression through fuzzy k-means clustering
BackgroundOrganisms simplify the orchestration of gene expression by coregulating genes whose products function together in the cell. Many proteins serve different roles depending on the demands ofExpand
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Stress-activated genomic expression changes serve a preparative role for impending stress in yeast.
Yeast cells respond to stress by mediating condition-specific gene expression changes and by mounting a common response to many stresses, called the environmental stress response (ESR). Giaever etExpand
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Conservation and Evolution of Cis-Regulatory Systems in Ascomycete Fungi
Relatively little is known about the mechanisms through which gene expression regulation evolves. To investigate this, we systematically explored the conservation of regulatory networks in fungi byExpand
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Genome-wide characterization of the Zap1p zinc-responsive regulon in yeast.
The Zap1p transcription factor senses cellular zinc status and increases expression of its target genes in response to zinc deficiency. Previously known Zap1p-regulated genes encode the Zrt1p, Zrt2p,Expand
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The genomics of yeast responses to environmental stress and starvation
Abstract. Unicellular organisms such as yeast have evolved to survive constant fluctuations in their external surroundings by rapidly adapting their internal systems to meet the challenges of eachExpand
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Cellular Memory of Acquired Stress Resistance in Saccharomyces cerevisiae
Cellular memory of past experiences has been observed in several organisms and across a variety of experiences, including bacteria “remembering” prior nutritional status and amoeba “learning” toExpand
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A dynamic model of proteome changes reveals new roles for transcript alteration in yeast
By characterizing dynamic changes in yeast protein abundance following osmotic shock, this study shows that the correlation between protein and mRNA differs for transcripts that increase versusExpand
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