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Compound heterozygous ZMPSTE24 mutations reduce prelamin A processing and result in a severe progeroid phenotype
TLDR
A genetic cause has now been implicated following the identification of de novo heterozygous mutations in the LMNA gene in the majority of HGPS patients, which is an extremely rare but devastating disorder that mimics premature aging. Expand
Severe mandibuloacral dysplasia caused by novel compound heterozygous ZMPSTE24 mutations in two Japanese siblings
TLDR
It is concluded that ZMPSTE24 deficiency results in accumulation of farnesylated prelamin A, which may be responsible for cellular toxicity and the MAD phenotype. Expand
Identification and validation of QTLs conferring resistance to sorghum downy mildew (Peronosclerospora sorghi) and Rajasthan downy mildew (P. heteropogoni) in maize
TLDR
The results confirmed that some common QTLs contribute to both SDM and RDM resistance, while additional loci might specifically govern resistance to SDM. Expand
Field study reveals core plant microbiota and relative importance of their drivers
TLDR
This study revealed key hub microorganisms in the core microbiome networks of sugarcane leaves, stalks, roots and rhizosphere soil despite location and time-associated shifts in the community assemblages. Expand
Maize SUT1 functions in phloem loading
TLDR
It is demonstrated that ZmSUT1 functions to phloem load sucrose in maize leaves, and an additional mutant allele, sut1-m4, is identified, confirming that the mutation of SUT1 is responsible for the impairment inphloem loading. Expand
A Connected Set of Genes Associated with Programmed Cell Death Implicated in Controlling the Hypersensitive Response in Maize
TLDR
An association mapping strategy based on the Mutant Assisted Gene Identification and Characterization approach to identify naturally occurring allelic variants associated with phenotypic variation in HR, and the extent of genome-wide LD is examined. Expand
Novel mutations in typical and atypical genetic loci through exome sequencing in autosomal recessive cerebellar ataxia families
TLDR
This study revealed novel variations in three genes, c10orf2, CLN6, and SACS, that have so far not been reported in India and demonstrates the utility of whole exome screening in clinics for early diagnosis. Expand
Identificationof resistance sources to banded leaf and sheath blight (Rhizoctonia solani f. sp. sasakil) in maize
The Banded leaf and sheath blight (BlSB) disease, incited by Rhizoctonia solani f. sp. sasakii, causes considerable damage to maize (Zea mays L.) worldwide, particularly in the tropical Asia.Expand
Simple sequence repeat (SSR) polymorphism in the tropical Asian maize inbred lines differing in resistance to banded leaf and sheath blight (Rhizoctonia solani f. sp. sasakii)
TLDR
Besides revealing high genetic diversity among the tropical/sub-tropical Inbred lines, cluster analysis using SSR dataset clearly demonstrated the genetic distinctness of the CIMMYT-ARMP lines vis-a-vis maize inbreds developed in India. Expand
Differentiation of the American and Oriental Maydeae Accessions Using the Maize Simple Sequence Repeat (SSR) Markers
TLDR
Cluster analysis and Principal Component Analysis based on the SSR data clearly indicated significant genetic divergence between the Oriental Maydeae and the American May deae accessions, as well as between Coix aquatica and Chionachne koenigii. Expand
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