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A Comprehensive Proteomics and Genomics Analysis Reveals Novel Transmembrane Proteins in Human Platelets and Mouse Megakaryocytes Including G6b-B, a Novel Immunoreceptor Tyrosine-based Inhibitory
The platelet surface is poorly characterized due to the low abundance of many membrane proteins and the lack of specialist tools for their investigation. In this study we identified novel humanExpand
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Proteomics applied to the study of platelet-related diseases: aiding the discovery of novel platelet biomarkers and drug targets.
Platelets play a fundamental role in hemostasis. Because they do not have a nucleus, proteomics is an ideal way to approach their biochemistry. Platelet proteomics is still a young field that emergedExpand
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Species differences in the localization of soluble guanylyl cyclase subunits in monkey and rat brain
Nitric oxide (NO) exerts most of its physiological effects through activation of a predominantly soluble guanylyl cyclase (sGC). In mammalian cells sGC exists as a heterodimer of α and β subunits.Expand
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Applicability of 2-DE to assess differences in the protein profile between cold storage and not cold storage in nectarine fruits.
Cold storage is being used to increase nectarine fruits' postharvest life. However, low temperatures lead to chilling injury and limit their commercial quality and value. In this study a proteomicExpand
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Neuropeptide precursor VGF is genetically associated with social anhedonia and underrepresented in the brain of major mental illness: its downregulation by DISC1.
In a large Scottish pedigree, disruption of the gene coding for DISC1 clearly segregates with major depression, schizophrenia and related mental conditions. Thus, study of DISC1 may provide a clue toExpand
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Two-dimensional gel electrophoresis in platelet proteomics research.
  • A. Garcia
  • Medicine
  • Methods in molecular medicine
  • 2007
Proteomics technology allows a comprehensive and efficient analysis of the proteome and has become an indispensable tool in biomedical research. Since the late 80s, advances on mass spectrometry (MS)Expand
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Division of the pedicle in the Abbé flap.
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Platelet proteomics: state of the art and future perspective.
Platelets pose unique challenges to cell biologists due to their lack of nucleus and low levels of messenger RNA. Platelets cannot be cultured in great abundance or manipulated using commonExpand
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High-resolution two-dimensional gel electrophoresis analysis of atrial tissue proteome reveals down-regulation of fibulin-1 in atrial fibrillation.
BACKGROUND Atrial fibrillation (AF) is the most common cardiac arrhythmia found in clinical practice. We combined high-resolution two-dimensional gel electrophoresis (2-DE) and mass spectrometry (MS)Expand
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Clinical proteomics in platelet research: challenges ahead
  • A. Garcia
  • Biology, Medicine
  • Journal of thrombosis and haemostasis : JTH
  • 1 August 2010
See also Maynard DM, Heijnen HFG, Gahl WA, Gunay‐Aygun M. The α‐granule proteome: novel proteins in normal and ghost granules in gray platelet syndrome. This issue, pp 1786–96.
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