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Economic foundations of cost-effectiveness analysis.
To address controversies in the applications of cost-effectiveness analysis, we investigate the principles underlying the technique and discuss the implications for the evaluation of medical… Expand
Cost-Effectiveness of Dabigatran Compared With Warfarin for Stroke Prevention in Atrial Fibrillation
BACKGROUND Warfarin reduces the risk for ischemic stroke in patients with atrial fibrillation (AF) but increases the risk for hemorrhage. Dabigatran is a fixed-dose, oral direct thrombin inhibitor… Expand
Low-molecular-weight heparins compared with unfractionated heparin for treatment of acute deep venous thrombosis. A meta-analysis of randomized, controlled trials.
BACKGROUND Low-molecular-weight heparins may simplify the management of deep venous thrombosis. A critical clinical issue is whether this more convenient therapy is as safe and effective as treatment… Expand
Systematic Review: The Effects of Growth Hormone on Athletic Performance
The use of human growth hormone to improve athletic performance has recently received worldwide attention. This practice, often called sports doping, is banned by most professional sports leagues and… Expand
American Association of Clinical Endocrinologists' Comprehensive Diabetes Management Algorithm 2013 Consensus Statement
Alan J. Garber, MD, PhD, FACE; Martin J. Abrahamson, MD; Joshua I. Barzilay, MD, FACE; Lawrence Blonde, MD, FACP, FACE; Zachary T. Bloomgarden, MD, MACE; Michael A. Bush, MD; Samuel Dagogo-Jack, MD,… Expand
Cost-effectiveness of screening BRCA1/2 mutation carriers with breast magnetic resonance imaging.
CONTEXT Women with inherited BRCA1/2 mutations are at high risk for breast cancer, which mammography often misses. Screening with contrast-enhanced breast magnetic resonance imaging (MRI) detects… Expand
Systematic Review: The Safety and Efficacy of Growth Hormone in the Healthy Elderly
Context Human growth hormone (GH) is widely sold and used as an antiaging agent. Contributions The researchers reviewed all clinical trials of GH to determine if it is safe and effective in the… Expand
Consequences of health trends and medical innovation for the future elderly.
Recent innovations in biomedicine seem poised to revolutionize medical practice. At the same time, disease and disability are increasing among younger populations. This paper considers how these… Expand
Cost-Effectiveness of Alternative Test Strategies for the Diagnosis of Coronary Artery Disease
Several current tests for the noninvasive diagnosis of coronary artery disease are more expensive and more accurate than traditional exercise electrocardiography (1-3). Little information exists to… Expand