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Oviduct extracellular vesicles protein content and their role during oviduct-embryo cross-talk.
TLDR
This study demonstrated for the first time the substantial differences between in vivo and in vitro oviduct EVs secretion/content and showed that in vitro-produced embryos were able to internalize in vivo EVs during culture with a functional effect in the embryo development.
Oviduct fluid extracellular vesicles regulate polyspermy during porcine invitro fertilisation.
TLDR
Findings show that poEVs are key components of porcine OF and may play roles in Porcine fertilisation and polyspermy regulation, suggesting that supplementation with po EVs is a reliable strategy to decrease porcinespermy and improve invitro embryo production outcomes.
Magnetite-Gold nanohybrids as ideal all-in-one platforms for theranostics
TLDR
For the first time, Fe3O4-Au hybrids are conjugated with two fluorescent dyes or the combination of drug and dye allowing the simultaneous tracking of the nanoparticle vehicle and the drug cargo in vitro and in vivo.
Extravasating Neutrophils Open Vascular Barrier and Improve Liposomes Delivery to Tumors.
TLDR
It is hypothesized that microleakage and macroleakages are subsequent steps of the extravasation process corresponding to liposomes transport through endothelial and subendothelial barriers, and across studied tumor types neutrophils counts correlated with leakage frequencies.
Steroid hormones regulate sperm-oviduct interactions in the bovine.
TLDR
The hypothesis that the dynamic changes in steroid hormones around the time of ovulation regulate the formation of the sperm reservoir and the timed delivery of capacitated spermatozoa to the site of fertilization is supported.
Multifunctional Fe3O4-Au Nanoparticles for the MRI Diagnosis and Potential Treatment of Liver Cancer
TLDR
Fe3O4-Au bifunctional nanoparticles showed a good theranostic potential for liver cancer treatment, since the r2 relaxivity is higher than the corresponding values for commercial T2 contrast agents and the Specific Absorption Rate (SAR) value obtained is enough to make them suitable as heat mediators for Magnetic Fluid Hyperthermia.
Consecutive entosis stages in human substrate-dependent cultured cells
TLDR
In substrate-dependent cultures, entosis requires microfilaments, microtubules and the Golgi complex for cell invasion, but not for internalized cell degradation, so it is demonstrated that actin filaments in the entotic as well as invading cells were crucial for entosis.
Size-selected Fe3O4–Au hybrid nanoparticles for improved magnetism-based theranostics
TLDR
The functional in vitro hyperthermia test for the 4T1 mouse breast cancer cell line demonstrated 80% and 100% cell death for immediate exposure and after precultivation of the cells for 6 h with 25 nm Fe3O4–Au hybrid nanomaterials, respectively confirms that the improved magnetic properties of the bifunctional particles present a next step in magnetic-particle-based theranostics.
Novel method for rapid toxicity screening of magnetic nanoparticles
TLDR
A label-free method for assessing nanoparticle toxicity using the rapid (less than 30 minutes) measurement of ROS with a novel nanoelectrode is developed.
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