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Transcription Deregulation at the 15q25 Locus in Association with Lung Adenocarcinoma Risk
Purpose: We characterized the candidacy of the six candidate genes mapping in the chromosome 15q25 locus, which was previously reported as associated with lung cancer risk, and confirmed the locusExpand
Mouse Genome-Wide Association Mapping Needs Linkage Analysis to Avoid False-Positive Loci
We carried out genome-wide association (GWA) studies in inbred mouse strains characterized for their lung tumor susceptibility phenotypes (spontaneous or urethane-induced) with panels of 12,959 (13K)Expand
Identification and functional characterization of the candidate tumor suppressor gene TRIT1 in human lung cancer
tRNA-isopentenyltransferase (tRNA-IPT) catalyses the addition of N6-isopentenyladenosine (i6A) on residue 37 of tRNA molecules that bind codons starting with uridine. Post-transcriptionalExpand
Unique microRNA-profiles in EGFR-mutated lung adenocarcinomas
The findings of mutations and the development of targeted therapies have improved lung cancer management. Still, the prognosis remains poor, and we need to know more about the genetic and epigeneticExpand
Association of lung adenocarcinoma clinical stage with gene expression pattern in noninvolved lung tissue
Associations between clinical outcome of cancer patients and the gene expression signature in primary tumors at time of diagnosis have been reported. To test whether gene expression patterns inExpand
FGFR4 Gly388Arg polymorphism may affect the clinical stage of patients with lung cancer by modulating the transcriptional profile of normal lung
The association of the fibroblast growth factor receptor 4 (FGFR4) Gly388Arg polymorphism with clinical stage and overall survival in a series of 541 Italian lung adenocarcinoma (ADCA) patientsExpand
A locus on mouse chromosome 2 is involved in susceptibility to congenital hypothyroidism and contains an essential gene expressed in thyroid.
We report here the mapping of a chromosomal region responsible for strain-specific development of congenital hypothyroidism in mice heterozygous for null mutations in genes encoding Nkx2-1/Titf1 andExpand
Beyond genome-wide association studies: genetic heterogeneity and individual predisposition to cancer.
Genome-wide association studies (GWAS) using population-based designs have identified many genetic loci associated with risk of a range of complex diseases including cancer; however, each locusExpand
Promoter polymorphisms and transcript levels of nicotinic receptor CHRNA5.
Chromosomal locus 15q25, implicated in lung cancer risk and nicotine dependence, shows extensive linkage disequilibrium that complicates identification of causal variation. Cholinergic receptorExpand
Genome-wide single nucleotide polymorphism analysis of lung cancer risk detects the KLF6 gene.
A genome-wide association analysis using the Affymetrix 100K SNP array was carried out in a case-control study of lung cancer. Allele frequencies were estimated initially in DNA pools. SignificantExpand