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S100B and S100A6 Differentially Modulate Cell Survival by Interacting with Distinct RAGE (Receptor for Advanced Glycation End Products) Immunoglobulin Domains*
TLDR
Comparison of the interaction of two S100 proteins, S100B and S100A6, with RAGE by in vitro assay and in culture of human SH-SY5Y neuroblastoma cells suggests that the receptor for advanced glycation end products (RAGE) plays important roles in mediating S100 protein-induced cellular signaling. Expand
Enlarged meristems and delayed growth in plp mutants result from lack of CaaX prenyltransferases.
TLDR
Pluripetala mutants lead to insights into the mechanism of meristem homeostasis and provide a unique in vivo system for studying the functional role of prenylation in eukaryotes. Expand
Structural and functional insights into RAGE activation by multimeric S100B
TLDR
The structural and the binding data suggest that tetrameric S100B triggers RAGE activation by receptor dimerisation, which caused stronger activation of cell growth than S 100B dimer and promoted cell survival. Expand
Pathologies involving the S100 proteins and RAGE.
TLDR
The most recent developments focussing on the biological functions of the S100 proteins are reviewed and the presently available S100-specific mouse models and their possible use as human disease models are discussed. Expand
Calcium-regulated intramembrane proteolysis of the RAGE receptor.
TLDR
It is shown that sRAGE is also produced through regulated intramembrane proteolysis of the RAGE receptor, which is catalyzed by ADAM10 and the gamma-secretase and that calcium is an essential regulator of RAGE processing. Expand
Site-Specific Blockade of RAGE-Vd Prevents Amyloid-β Oligomer Neurotoxicity
TLDR
The data indicate that distinct regions of RAGE are involved in Aβ-induced cellular and neuronal toxicity with respect to the Aβ aggregation state, and they suggest the blockage of particular sites of the receptor as a potential therapeutic strategy to attenuate neuronal death. Expand
Genome-Wide Analysis of Gene Expression Profiles Associated with Cell Cycle Transitions in Growing Organs of Arabidopsis1[w]
TLDR
Kinematic analysis, flowcytometry, and microarray analysis were combined to characterize cell cycle regulation during the growth process of leaves 1 and 2 of Arabidopsis (Arabidopsis thaliana) and identified a high confidence set of 131 proliferation genes. Expand
Developmentally Controlled Farnesylation Modulates AtNAP1;1 Function in Cell Proliferation and Cell Expansion during Arabidopsis Leaf Development1
TLDR
Molecular, biochemical, and kinetic studies of AtNNAP1;1 gain- or loss-of-function mutants indicate that AtNAP 1;1 promotes cell proliferation or cell expansion in a developmental context and as a function of the farnesylation status of the protein. Expand
Protein farnesylation in plants--conserved mechanisms but different targets.
TLDR
The identification of protein farnesyltransferase substrates, together with the genetic analysis of mutants that are deficient in proteinFarnesylation, should significantly increase knowledge of this form of protein modification in plants. Expand
Missing C‐terminal filaggrin expression, NFkappaB activation and hyperproliferation identify the dog as a putative model to study epidermal dysfunction in atopic dermatitis
TLDR
Missing C‐terminal filaggrin expression, NFkappaB activation and hyperproliferation identify the dog as a putative model to study epidermal dysfunction in atopic dermatitis. Expand
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