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- Publications
- Influence
Melatonin as a natural ally against oxidative stress: a physicochemical examination
Abstract: Oxidative stress has been proven to be related to the onset of a large number of health disorders. This chemical stress is triggered by an excess of free radicals, which are generated in… Expand
Melatonin: an ancient molecule that makes oxygen metabolically tolerable
- L. Manchester, A. Coto‐Montes, +6 authors R. Reiter
- Biology, Medicine
- Journal of pineal research
- 1 November 2015
Melatonin is remarkably functionally diverse with actions as a free radical scavenger and antioxidant, circadian rhythm regulator, anti‐inflammatory and immunoregulating molecule, and as an… Expand
On the free radical scavenging activities of melatonin's metabolites, AFMK and AMK
The reactions of N1‐acetyl‐N2‐formyl‐5‐methoxykynuramine (AFMK) and N1‐acetyl‐5‐methoxykynuramine (AMK) with •OH, •OOH, and •OOCCl3 radicals have been studied using the density functional theory.… Expand
Melatonin: exceeding expectations.
Melatonin is a small, highly conserved indole with numerous receptor-mediated and receptor-independent actions. Receptor-dependent functions include circadian rhythm regulation, sleep, and cancer… Expand
Phytomelatonin: Assisting Plants to Survive and Thrive
- R. J. Reiter, D. Tan, Zhou Zhou, M. Cruz, L. Fuentes-Broto, A. Galano
- Biology, Medicine
- Molecules
- 1 April 2015
This review summarizes the advances that have been made in terms of the identified functions of melatonin in plants. Melatonin is an endogenously-produced molecule in all plant species that have been… Expand
Food Antioxidants: Chemical Insights at the Molecular Level.
- A. Galano, G. Mazzone, Ruslán Álvarez-Diduk, Tiziana Marino, J. R. Álvarez-Idaboy, N. Russo
- Chemistry, Medicine
- Annual review of food science and technology
- 2 March 2016
In this review, we briefly summarize the reliability of the density functional theory (DFT)-based methods to accurately predict the main antioxidant properties and the reaction mechanisms involved in… Expand
A computational methodology for accurate predictions of rate constants in solution: Application to the assessment of primary antioxidant activity
- A. Galano, J. R. Álvarez-Idaboy
- Chemistry, Medicine
- J. Comput. Chem.
- 30 October 2013
TLDR
Melatonin reduces lipid peroxidation and membrane viscosity
Lipid peroxidation (LPO) occurs as a result of the oxidative deterioration of polyunsaturated fatty acids (PUFA), i.e., those that contain two or more carbon–carbon double bonds. The most apparent… Expand
On the direct scavenging activity of melatonin towards hydroxyl and a series of peroxyl radicals.
- A. Galano
- Chemistry, Medicine
- Physical chemistry chemical physics : PCCP
- 29 March 2011
The reactions of melatonin (MLT) with hydroxyl and several peroxyl radicals have been studied using the Density Functional Theory, specifically the M05-2X functional. Five mechanisms of reaction have… Expand
Radical scavenging ability of gallic acid toward OH and OOH radicals. Reaction mechanism and rate constants from the density functional theory.
Gallic acid is a ubiquitous compound, widely distributed in the vegetal kingdom and frequently found in the human diet. In the present work, its primary antioxidant activity has been investigated… Expand