• Publications
  • Influence
The ups and downs of peer review.
This article traces the history of peer review of scientific publications, plotting the development of the process from its inception to its present-day application. We discuss the merits of peerExpand
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A Critical Role for LTA4H in Limiting Chronic Pulmonary Neutrophilic Inflammation
Smoke Gets in Your Lungs Chronic obstructive pulmonary disease (COPD) is a leading cause of death in the United States, primarily caused by cigarette smoking. The chronic inflammation that leads toExpand
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A Novel Proteolytic Cascade Generates an Extracellular Matrix-Derived Chemoattractant in Chronic Neutrophilic Inflammation12
Chronic neutrophilic inflammation is a manifestation of a variety of lung diseases including cystic fibrosis (CF). There is increasing evidence that fragments of extracellular matrix proteins, suchExpand
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Acquired cystic fibrosis transmembrane conductance regulator dysfunction in the lower airways in COPD.
BACKGROUND Cigarette smoke and smoking-induced inflammation decrease cystic fibrosis transmembrane conductance regulator (CFTR) activity and mucociliary transport in the nasal airway and culturedExpand
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Matrix Metalloproteinase 9 Activity Enhances Host Susceptibility to Pulmonary Infection with Type A and B Strains of Francisella tularensis1
A striking feature of pulmonary infection with the Gram-negative intracellular bacterium Francisella tularensis, a category A biological threat agent, is an intense accumulation of inflammatoryExpand
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Human Neutrophil Elastase-Mediated Cleavage Sites of MMP-9 and TIMP-1: Implications to Cystic Fibrosis Proteolytic Dysfunction
Cystic fibrosis (CF) is a lethal genetic disorder characterized by airway remodeling and inflammation, leading to premature death. Recent evidence suggests the importance of protease activity in CFExpand
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Matrix metalloprotease-9 dysregulation in lower airway secretions of cystic fibrosis patients.
  • A. Gaggar, Y. Li, +5 authors J. Clancy
  • Biology, Medicine
  • American journal of physiology. Lung cellular and…
  • 1 July 2007
Matrix metalloproteases (MMPs) are proteolytic enzymes that regulate extracellular matrix turnover and aid in restoring tissue architecture following injury. There is an emerging role forExpand
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Innate immunity in cystic fibrosis lung disease.
Chronic lung disease determines the morbidity and mortality of cystic fibrosis (CF) patients. The pulmonary immune response in CF is characterized by an early and non-resolving activation of theExpand
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Negative affect moderates the relation between dieting and binge eating.
OBJECTIVE Although laboratory experiments suggest that negative affect inductions potentiate the relation between dieting and disinhibited eating, little research has tested whether this findingExpand
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Protective effect of suppressing STAT3 activity in LPS-induced acute lung injury.
Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are diseases with high mortality. Macrophages and neutrophils are responsible for inflammatory responses in ALI and ARDS, whichExpand
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