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Targeted Deficiency or Cytosolic Truncation of the VE-cadherin Gene in Mice Impairs VEGF-Mediated Endothelial Survival and Angiogenesis
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Smooth muscle cells and fibroblasts of the coronary arteries derive from epithelial-mesenchymal transformation of the epicardium
TLDR
It is concluded that epithelial-mesenchymal transformation of the epicardial lining delivers the smooth muscle cells and fibroblasts of the coronary arterial vessel wall from the early stage of endothelial tube formation to the late stage of mature vessel wall composition.
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Basics of Cardiac Development for the Understanding of Congenital Heart Malformations
TLDR
Cardiovascular development is a complex interplay of many cell–cell and cell–matrix interactions and study of both (transgenic) animal models and human pathology is unravelling the mechanisms underlying congenital cardiac anomalies.
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Chapter
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VEGF: A modifier of the del22q11 (DiGeorge) syndrome?
TLDR
It is reported that absence of the Vegf164 isoform caused birth defects in mice, reminiscent of those found in del22q11 patients, and genetic data in mouse, fish and human indicate that VEGF is a modifier of cardiovascular birth defect in the del 22q11 syndrome.
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Double-Outlet Right Ventricle and Overriding Tricuspid Valve Reflect Disturbances of Looping, Myocardialization, Endocardial Cushion Differentiation, and Apoptosis in TGF-β2–Knockout Mice
TLDR
This data indicates that mice deficient in the TGF-β2 gene die around birth and show a variety of defects of different organs, including the heart, and which processes of cardiac morphogenesis are affected by the absence of this growth factor should be investigated.
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Comparative anatomy and ontogeny of the ductus arteriosus, a vascular outsider
TLDR
New data suggest that HOXB5 expression in the neural crest along the dorsal half of the sixth arch artery may be involved in the instigation of ductus arteriosus differentiation, and illustrates similarities and differences in morphogenesis and closure mechanisms among the species.
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In vitro epithelial-to-mesenchymal transformation in human adult epicardial cells is regulated by TGFβ-signaling and WT1
TLDR
It is shown that TGFβ-induced EMT is dependent on type-1 TGF β receptor activity and can be inhibited by soluble VCAM-1, and epicardial-specific knockdown of Wilms tumor-1 (WT1) induces the process of EMT in human adult epicardials cells, through transcriptional regulation of platelet-derived growth factor receptor alpha (Pdgfrα), Snai1 and VCAM1.
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TGF β 2 knockout mice have multiple developmental defects that are non-overlapping with other TGF β knockout phenotypes
TLDR
Targeted disruption of the TGF β 2 gene was undertaken to determine its essential role in vivo to exhibit perinatal mortality and a wide range of developmental defects for a single gene disruption.
Expression patterns of the paired-related homeobox genes MHox/Prx1 and S8/Prx2 suggest roles in development of the heart and the forebrain
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