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Isolation, structures, and structure - cytotoxic activity relationships of withanolides and physalins from Physalis angulata.
TLDR
Phytochemical investigation of Physalis angulata indicated that withanolides and physalins with 4beta-hydroxy-2-en-1-one and 5beta,6beta-epoxy moieties are potential cytotoxic agents.
Phenanthroindolizidine alkaloids from the stems of Ficus septica.
TLDR
Eight new alkaloids, namely, ficuseptines B-D (1-3), 10R,13aR-tylophorine N-oxide (4, 5, 6, 7, and 8), and 10S, 13aS-isotylocrebrine (8) were isolated from a methanol extract of the stems of Ficus septica by means of spectroscopic data interpretation.
Constituents of the roots of Clausena lansium and their potential anti-inflammatory activity.
Eight new carbazole alkaloids, claulamines C (1), D (2), and E (5) and clausenalines B-F (3, 4, 6-8), four new coumarins, clausemarins A-D (9-12), and 43 known compounds were isolated from the roots
A rapid and simple determination of protoberberine alkaloids in Rhizoma Coptidis by 1H NMR and its application for quality control of commercial prescriptions.
TLDR
A highly specific and sensitive method using (1)H NMR has been developed for the quantitative determination of protoberberine alkaloids berberine, palmatine, coptisine and jatrorrhizine in Coptis species and their commercial traditional Chinese medicine prescriptions.
Cytotoxic and antimalarial beta-carboline alkaloids from the roots of Eurycoma longifolia.
TLDR
Three new beta-carboline alkaloids were isolated from the roots of Eurycoma longifolia and demonstrated significant cytotoxicity against human lung cancer and human breast cancer cell lines.
Cytotoxic phenanthroindolizidine alkaloids from the roots of Ficus septica.
Activity-monitored fractionation of the CHCl3 solubles of the MeOH extract of the roots of Ficus septica using cytotoxicity assay led to the isolation of twenty phenanthroindolizidine alkaloids,
Physanolide A, a novel skeleton steroid, and other cytotoxic principles from Physalis angulata.
TLDR
Physalins B, D, and F showed strong cytotoxicity against multiple tumor cell lines, including KB, A431, HCT-8, PC-3, and ZR751, with EC(50) values less than 4 microg/mL.
Flavonoids and ent-labdane diterpenoids from Andrographis paniculata and their antiplatelet aggregatory and vasorelaxing effects
TLDR
Four flavonoids showed potent inhibition of collagen, arachidonic acid, thrombin, and platelet activation factor induced platelet aggregation and a diterpenoid demonstrated moderate vasorelaxing effect in isolated rat thoracic aorta.
Cytotoxic and antimalarial constituents from the roots of Eurycoma longifolia.
TLDR
Sixty-five compounds were isolated from the roots of Eurycoma longifolia and characterized by comprehensive analyses of their 1D and 2D NMR, and mass spectral data, which provided a clear reference to the scientists who are interested on this field.
Isolation of a Natural Antioxidant, Dehydrozingerone from Zingiber officinale and Synthesis of Its Analogues for Recognition of Effective Antioxidant and Antityrosinase Agents
TLDR
From the present study, it was observed that both number and position of hydroxyl groups on aromatic ring and a double bond between C-3 and C-4 played a critical role in exerting the antioxidant and antityrosinase activity.
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