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Pharmacokinetics and metabolism of the anti-inflammatory agent Voltaren.
Diclofenac sodium, the active substance of Voltaren®, is totally absorbed following both oral and rectal administration and is excreted, mainly in metabolised form, partly in the urine and partly inExpand
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Pharmacokinetics of the enantiomers of acenocoumarol in man.
1 The pharmacokinetics of R(+)-, S(-)- and R,S(+/-)-acenocoumarol were studied in healthy volunteers after administration of single oral and intravenous doses. 2 After both oral and i.v.Expand
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Absolute Bioavailability of Carbamazepine After Oral Administration of a 2% Syrup
Summary: Two healthy male volunteers received 10 mg carbamazepine (CBZ) as a 2‐h constant‐rate intravenous (i.v.) infusion and 100 mg 15N‐labeled CBZ as a 2% oral suspension, concomitantly. The twoExpand
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Plasma concentrations and haemodynamic effects of nitroglycerin during and after intravenous infusion in healthy volunteers
SummaryThe effects of nitroglycerin, infused intravenously at 3.4 and 7.5 µg/min over 30 min, on haemodynamic parameters were determined in the morning and the afternoon in a randomized,Expand
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Gas chromatographic mass spectrometric determination of 1,2,3-propanetrioltrinitrate (nitroglycerin) in human plasma using the nitrogen-15 labelled compound as internal standard.
A method for the quantitative determinatio of 1,2,3-propanetrioltrinitrate (nitroglycerin) in human plasma by gas chromatography mass spectrometry has been developed. After addition of 1,2,3 andExpand
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Bioequivalence of carbamazepine chewable and conventional tablets: single-dose and steady-state studies.
Single-dose and steady-state studies were carried out on separate occasions to examine the bioequivalence of the newly formulated carbamazepine chewable tablet. In the single-dose study, the plasmaExpand
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Diffusion of oxyphenbutazone into synovial fluid, synovial tissue, joint cartilage and cerebrospinal fluid
SummaryThe diffusion of oxyphenbutazone into synovial and cerebrospinal fluids and synovium and joint cartilage was investigated in 25 patients receiving short-term treatment. In the synovial fluid,Expand
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GLC determination of carbamazepine suitable for pharmacokinetic studies.
A GLC determination of carbamazepine in plasma and urine is described. It is performed by injecting the cyano derivative, which, in contrast to carbamazepine, has bood GLC properties. The method isExpand
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Human pharmacological studies of a new transdermal system containing nitroglycerin
SummaryA new transdermal therapeutic system (TTS) for the administration of nitroglycerin (NTG) was tested in human pharmacological studies in 26 healthy volunteers. Plasma concentrations andExpand
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