• Publications
  • Influence
Stat3 and MMP7 contribute to pancreatic ductal adenocarcinoma initiation and progression.
Chronic pancreatitis is a well-known risk factor for pancreatic ductal adenocarcinoma (PDA) development in humans, and inflammation promotes PDA initiation and progression in mouse models of theExpand
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The chromatin regulator Brg1 suppresses formation of intraductal papillary mucinous neoplasm and pancreatic ductal adenocarcinoma
Pancreatic ductal adenocarcinoma (PDA) develops through distinct precursor lesions, including pancreatic intraepithelial neoplasia (PanIN) and intraductal papillary mucinous neoplasia (IPMN).Expand
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Irradiation-induced progenitor cell death in the developing brain is resistant to erythropoietin treatment and caspase inhibition
AbstractOne hemisphere of postnatal day 8 (P8) rats or P10 mice was irradiated with a single dose of 4–12 Gy, and animals were killed from 2 h to 8 weeks after irradiation (IR). In the subventricularExpand
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Bmi1 is required for regeneration of the exocrine pancreas in mice.
BACKGROUND & AIMS Bmi1 is a member of the Polycomb protein family and represses transcription by modifying chromatin organization at specific promoters. Bmi1 is implicated in the control of stem cellExpand
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Brg1 plays an essential role in development and homeostasis of the duodenum through regulation of Notch signaling
Brg1, a core subunit of the SWI/SNF chromatin remodeling complex, is essential for development and homeostasis of various organs. However, the functional role of Brg1 in intestinal development andExpand
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Molecular mechanism of intraductal papillary mucinous neoplasm and intraductal papillary mucinous neoplasm‐derived pancreatic ductal adenocarcinoma
  • A. Fukuda
  • Medicine
  • Journal of hepato-biliary-pancreatic sciences
  • 1 July 2015
Pancreatic ductal adenocarcinoma (PDA) is one of the most lethal human malignancies. Dissecting the mechanisms underlying PDA development is important for developing early detection methods andExpand
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Title EP 4 Receptor ‒ Associated Protein in Macrophages AmelioratesColitis and Colitis-Associated Tumorigenesis
Prostaglandin E2 plays important roles in the maintenance of colonic homeostasis. The recently identified prostaglandin E receptor (EP) 4–associated protein (EPRAP) is essential for anExpand
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  • Open Access
Epithelial EP4 plays an essential role in maintaining homeostasis in colon
Colonic epithelial cells comprise the mucosal barrier, and their dysfunction promotes microbial invasion from the gut lumen and induces the development of intestinal inflammation. The EP4 receptor isExpand
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