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Integrated molecular analysis of clear-cell renal cell carcinoma
Clear-cell renal cell carcinoma (ccRCC) is the most prevalent kidney cancer and its molecular pathogenesis is incompletely understood. Here we report an integrated molecular study of ccRCC in which… Expand
Whole-genome sequencing of liver cancers identifies etiological influences on mutation patterns and recurrent mutations in chromatin regulators
Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related death worldwide. We sequenced and analyzed the whole genomes of 27 HCCs, 25 of which were associated with hepatitis B or C… Expand
Whole-genome mutational landscape and characterization of noncoding and structural mutations in liver cancer
Liver cancer, which is most often associated with virus infection, is prevalent worldwide, and its underlying etiology and genomic structure are heterogeneous. Here we provide a whole-genome… Expand
International network of cancer genome projects
The International Cancer Genome Consortium (ICGC) was launched to coordinate large-scale cancer genome studies in tumours from 50 different cancer types and/or subtypes that are of clinical and… Expand
A scan for genetic determinants of human hair morphology: EDAR is associated with Asian hair thickness.
- A. Fujimoto, R. Kimura, +12 authors K. Tokunaga
- Biology, Medicine
- Human molecular genetics
- 15 March 2008
Hair morphology is one of the most differentiated traits among human populations. However, genetic backgrounds of hair morphological differences among populations have not been clarified yet. In… Expand
Mutational signatures associated with tobacco smoking in human cancer
Assessing smoke damage in cancer genomes We have known for over 60 years that smoking tobacco is one of the most avoidable risk factors for cancer. Yet the detailed mechanisms by which tobacco smoke… Expand
Whole-genome mutational landscape of liver cancers displaying biliary phenotype reveals hepatitis impact and molecular diversity.
- A. Fujimoto, M. Furuta, +35 authors H. Nakagawa
- Biology, Medicine
- Nature communications
- 30 January 2015
Intrahepatic cholangiocarcinoma and combined hepatocellular cholangiocarcinoma show varying degrees of biliary epithelial differentiation, which can be defined as liver cancer displaying biliary… Expand
A comprehensive assessment of somatic mutation detection in cancer using whole-genome sequencing
As whole-genome sequencing for cancer genome analysis becomes a clinical tool, a full understanding of the variables affecting sequencing analysis output is required. Here using tumour-normal sample… Expand
A Practical Genome Scan for Population-Specific Strong Selective Sweeps That Have Reached Fixation
Phenotypic divergences between modern human populations have developed as a result of genetic adaptation to local environments over the past 100,000 years. To identify genes involved in… Expand
Genomic characterization of biliary tract cancers identifies driver genes and predisposing mutations.
BACKGROUND & AIMS Biliary tract cancers (BTCs) are clinically and pathologically heterogeneous and respond poorly to treatment. Genomic profiling can offer a clearer understanding of their… Expand