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Anti-Trypanosoma cruzi effects of cyclosporin A derivatives: possible role of a P-glycoprotein and parasite cyclophilins.
Cyclophilins are target molecules for cyclosporin A (CsA), an immunosuppressive antimicrobial drug. We have previously reported the in vitro anti-Trypanosoma cruzi activity of H-7-94 and F-7-62Expand
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Extracellular matrix remodeling and TGF‐β1/Smad signaling in diabetic colon mucosa
Diabetes is associated with metabolic and functional alterations in the gut. Using an experimental model of streptozotocin (STZ)‐induced diabetes in rodents, we analyzed the extracellular matrixExpand
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Paraoxonase 1 gene polymorphisms and enzyme activities in coronary artery disease and its relationship to serum lipids and glycemia.
OBJECTIVES Oxidative stress and inflammation are important processes in development of atherosclerosis. Paraoxonase 1 (PON1) is a bioscavenger enzyme associated with inflammation and oxidativeExpand
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Solanesyl Diphosphate Synthase, an Enzyme of the Ubiquinone Synthetic Pathway, Is Required throughout the Life Cycle of Trypanosoma brucei
ABSTRACT Ubiquinone 9 (UQ9), the expected product of the long-chain solanesyl diphosphate synthase of Trypanosoma brucei (TbSPPS), has a central role in reoxidation of reducing equivalents in theExpand
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Amifostine (WR2721) Confers DNA Protection to in Vivo Cisplatin-Treated Murine Peripheral Blood Leukocytes
Amifostine [S-2-3-aminopropil amino ethyl phosphorotioic acid], a modulator agent for antineoplastic drugs involved in free radicals generation has given controversial results in cisplatin treatedExpand
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Morphological and biological characterization of cell line developed from bovine Echinococcus granulosus
The taeniid tapeworm Echinococcus granulosus is the causative agent of echinococcal disease, a major zoonosis with worldwide distribution. Several efforts to establish an in vitro model of E.Expand
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[Paraoxonase: its multiple functions and pharmacological regulation].
Homocysteine, a non-protein amino acid, important risk factor for atherosclerosis and thrombosis, causes dysfunction of vascular endothelial cells traduced in inadequate vasodilatation mechanism, isExpand
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Paraoxonasa: sus múltiples funciones y regulación farmacológica
Arch Cardiol Mex 2011;81(3):251-2601405-9940/$ - see front matter © 2011 Instituto Nacional de Cardiologia Ignacio Chavez. Publicado por Elsevier Mexico. Todos los derechosExpand
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Liver micro-organs transcribe albumin and clotting factors and increase survival of 92% hepatectomized rats.
BACKGROUND/AIMS Currently there is no effective non-surgical therapy for most patients with fulminant or end stage chronic liver disease. METHODS We have prepared rat liver micro-organs (LMOs),Expand
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Tratamiento y post-tratamiento con lonidamina en la línea celular de carcinoma colónico humano HT-29
Lonidamine (1-[2,4-dichlorophenyl methyl]-1H indazole-3-carboxylic acid), Ind, is an antitumoral drug acting on mitochondria and glucose metabolism. Cell growth and metabolic effects of Ind and drugExpand
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