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Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards
The authors identify the challenges and proposed set of minimal reporting guidelines for mouse and human MDSC are a heterogeneous population expanded in cancer and other chronic inflammatory conditions.
Neuropilin 1 is expressed on thymus-derived natural regulatory T cells, but not mucosa-generated induced Foxp3+ T reg cells
Neuropilin-1 surface expression discriminates between nT reg cells with stable expression and Nrp1 low iT reg cells showing inducible expression under inflammatory conditions.
Synthesis and incorporation of myelin polypeptides into CNS myelin
It was found that crude myelin fractions are highly enriched in mRNAs coding for the MBPs but not in mRNA coding for PLP, which suggests that whereas the bound polysomes synthesizing PLP are largely confined to the cell body, free polysome synthesizing MBPs are concentrated in oligodendrocyte processes involved in myelination, which explains the immediate incorporation of MBPs into the developing myelin sheath.
Immunological evidence for the association of p53 with a heat shock protein, hsc70, in p53-plus-ras-transformed cell lines.
The results provide clear immunological evidence for the specific association of a single heat shock protein, hsc70, with p53 in p53-plus-ras-transformed cell lines and suggest that the p 53-hsc70 protein complex could have functional significance in these transformed cells.
In liver fibrosis, dendritic cells govern hepatic inflammation in mice via TNF-alpha.
It is found that DC depletion completely abrogated the elevated levels of many inflammatory mediators that are produced in the fibrotic liver.
MyD88 inhibition amplifies dendritic cell capacity to promote pancreatic carcinogenesis via Th2 cells
MyD88 blockade exaggerates the ability of dendritic cells to promote the transition from chronic pancreatitis to pancreatic cancer.
Distinct populations of metastases‐enabling myeloid cells expand in the liver of mice harboring invasive and preinvasive intra‐abdominal tumor
It is found that in mice with intra‐abdominal malignancies, two distinct CD11b+Gr1+ populations with divergent phenotypic and functional properties accumulate in the liver, becoming the dominant hepatic leukocytes.
Distinct Requirements for IFNs and STAT1 in NK Cell Function1
It is demonstrated that both IFN-α and IFn-γ are required to maintain NK cell function and define a STAT1-dependent but partiallyIFN-independent pathway required for NK-mediated antitumor activity.
Type I IFN Modulates Innate and Specific Antiviral Immunity1
An unexpected role for type I IFN is revealed in coordinating the host response to viral infection and controlling inflammation in the absence of a direct effect on virus replication.
Dendritic cell populations with different concentrations of lipid regulate tolerance and immunity in mouse and human liver.
Human and mouse hepatic DCs are composed of distinct populations that contain different concentrations of lipid, which regulates immunogenic versus tolerogenic responses in the liver.