Efficacy of Divalproex vs Lithium and Placebo in the Treatment of Mania
Divalproex was as effective in rapid-cycling manic patients as in other patients and appears to be independent of prior responsiveness to lithium, while lithium was significantly more effective than placebo in reducing the symptoms of acute mania.
Chronic Unpredictable Stress Induces a Cognitive Deficit and Anxiety-Like Behavior in Rats that is Prevented by Chronic Antidepressant Drug Treatment
- C. Bondi, G. Rodriguez, G. Gould, A. Frazer, D. Morilak
- Psychology, BiologyNeuropsychopharmacology
In the present study, a rat model of chronic unpredictable stress (CUS) consistently induced a cognitive impairment in extradimensional set shifting capability in an attentional set shifting test, suggesting an alteration in function of the medial prefrontal cortex.
Leptin: A potential novel antidepressant
- Xin-Yun Lu, C. Kim, A. Frazer, Wei Zhang
- Biology, PsychologyProceedings of the National Academy of Sciences…
- 19 January 2006
Leptin, a hormone secreted from adipose tissue, was originally discovered to regulate body weight. The localization of the leptin receptor in limbic structures suggests a potential role for leptin in…
Effects of Chronic Antidepressant Treatments on Serotonin Transporter Function, Density, and mRNA Level
It appears that the SERT is downregulated by chronic administration of SSRIs but not other types of antidepressants; furthermore, the downregulation is not caused by decreases in SERT gene expression.
Effect of 1-(m-chlorophenyl)piperazine and 1-(m-trifluoromethylphenyl)piperazine on locomotor activity.
- I. Lucki, H. R. Ward, A. Frazer
- Biology, PsychologyJournal of Pharmacology and Experimental…
- 1 April 1989
It is suggested that chronic changes in 5-HT neurotransmission produce compensatory changes which alter the behavioral response to these piperazine agonists.
Onset and Early Behavioral Effects of Pharmacologically Different Antidepressants and Placebo in Depression
Early drug-specific behavioral changes were highly predictive of ultimate clinical response to the different ADs, results that could eventually be applied directly to clinical practice.
Differential actions of serotonin antagonists on two behavioral models of serotonin receptor activation in the rat.
Compared the actions of ketanserin and pipamperone and metergoline and methysergide on two behavioral responses in rats that are produced by the activation of 5-HT receptors, the order of relative potency for these drugs to block the head shake response was the same as their reported affinity for the 5- HT2 receptor, which suggests that the5-HT2 receptor is involved in the headshake response.
Effect of naltrexone on subjective alcohol response in subjects at high and low risk for future alcohol dependence
A differential response to naltrexone is suggested, based on paternal history of alcoholism and level of stimulation experienced during alcohol drinking, on response to a moderate dose of alcohol.
Serotonin Clearance In Vivo Is Altered to a Greater Extent by Antidepressant-Induced Downregulation of the Serotonin Transporter than by Acute Blockade of this Transporter
- S. Benmansour, W. A. Owens, M. Cecchi, D. Morilak, A. Frazer
- Medicine, BiologyJournal of Neuroscience
- 1 August 2002
Serotonin uptake, mediated by the serotonin transporter (SERT), is blocked acutely by antidepressants such as the selective serotonin reuptake inhibitors (SSRIs), but such blockade does not correlate…
VNS Therapy in Treatment-Resistant Depression: Clinical Evidence and Putative Neurobiological Mechanisms
Evidence from neuroimaging and other studies suggests that VNS therapy acts via innervation of the nucleus tractus solitarius, with secondary projections to limbic and cortical structures that are involved in mood regulation, including brainstem regions that contain serotonergic and noradrenergic regions that project to the forebrain.