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Obesity and prostate cancer: gene expression signature of human periprostatic adipose tissue
BackgroundPeriprostatic (PP) adipose tissue surrounds the prostate, an organ with a high predisposition to become malignant. Frequently, growing prostatic tumor cells extend beyond the prostatic… Expand
Genetic Polymorphism in EGF Is Associated with Prostate Cancer Aggressiveness and Progression-Free Interval in Androgen Blockade–Treated Patients
Purpose: Most prostate cancer patients develop resistance to androgen deprivation treatment, resulting in hormone resistance. Epidermal growth factor (EGF) activates several pro-oncogenic… Expand
Hypoxia and Prostate Cancer Aggressiveness: A Tale With Many Endings.
- A. Fraga, Ricardo Ribeiro, P. Príncipe, C. Lopes, R. Medeiros
- Clinical genitourinary cancer
- 1 August 2015
Angiogenesis, increased glycolysis, and cellular adaptation to hypoxic microenvironment are characteristic of solid tumors, including prostate cancer. These representative features are the… Expand
Human periprostatic white adipose tissue is rich in stromal progenitor cells and a potential source of prostate tumor stroma
- Ricardo Ribeiro, Cátia Monteiro, +10 authors R. Medeiros
- Biology, Medicine
- Experimental biology and medicine
- 1 October 2012
A body of growing evidence now implicates white adipose tissue as a relevant source of stromal progenitor cells recruited to the tumor microenvironment to form supportive tumor stroma. While the role… Expand
Hipoxia tumoral. Papel del factor inducible por hipoxia
HIF Hipoxia Cancer Los tumores solidos, por lo general, existen y progresan en un ambiente de hipoxia; asi se observa que las celulas tumorales son resistentes a la apoptosis y se acompanan de un… Expand
The HIF1A functional genetic polymorphism at locus +1772 associates with progression to metastatic prostate cancer and refractoriness to hormonal castration.
The hypoxia inducible factor 1 alpha (HIF1a) is a key regulator of tumour cell response to hypoxia, orchestrating mechanisms known to be involved in cancer aggressiveness and metastatic behaviour. In… Expand
The effects of combination therapy with dutasteride plus tamsulosin on clinical outcomes in men with symptomatic BPH: 4-year post hoc analysis of European men in the CombAT study
- O. Haillot, A. Fraga, +6 authors B. Morrill
- Prostate Cancer and Prostatic Diseases
- 19 April 2011
CombAT (Combination of Avodart and Tamsulosin) was a randomised, double-blind study in men (n=4844) aged ⩾50 years with a clinical diagnosis of BPH. Patients were randomised to daily tamsulosin 0.4… Expand
Pediatric kidney transplantation: a single center experience with 134 procedures.
Renal transplantation confers substantial benefits on children with end-stage renal disease (ESRD), including improved growth as well as longer and better quality of life. The aim of this study was… Expand
Molecular study of the PCA3 gene: genotypic analysis of PCA3 polymorphism -845G>A and metastatic prostate cancer.
- S. Fontenete, A. Nogueira, +4 authors R. Medeiros
- Genetic testing and molecular biomarkers
- 23 May 2012
AIMS The prostate cancer gene 3 (PCA3) is a prostate-specific, non-protein-coding RNA. It is overexpressed in prostate cancer compared with the normal prostate and has a negative expression in other… Expand
Sialyl-Tn identifies muscle-invasive bladder cancer basal and luminal subtypes facing decreased survival, being expressed by circulating tumor cells and metastases.
OBJECTIVES To evaluate the potential of sialyl-Tn (STn), a cancer-associated glycan antigen present in membrane glycoproteins, to improve a recent molecular model for stratification and… Expand