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Obesity and prostate cancer: gene expression signature of human periprostatic adipose tissue
BackgroundPeriprostatic (PP) adipose tissue surrounds the prostate, an organ with a high predisposition to become malignant. Frequently, growing prostatic tumor cells extend beyond the prostaticExpand
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  • Open Access
Genetic Polymorphism in EGF Is Associated with Prostate Cancer Aggressiveness and Progression-Free Interval in Androgen Blockade–Treated Patients
Purpose: Most prostate cancer patients develop resistance to androgen deprivation treatment, resulting in hormone resistance. Epidermal growth factor (EGF) activates several pro-oncogenicExpand
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Hypoxia and Prostate Cancer Aggressiveness: A Tale With Many Endings.
Angiogenesis, increased glycolysis, and cellular adaptation to hypoxic microenvironment are characteristic of solid tumors, including prostate cancer. These representative features are theExpand
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Human periprostatic white adipose tissue is rich in stromal progenitor cells and a potential source of prostate tumor stroma
A body of growing evidence now implicates white adipose tissue as a relevant source of stromal progenitor cells recruited to the tumor microenvironment to form supportive tumor stroma. While the roleExpand
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Hipoxia tumoral. Papel del factor inducible por hipoxia
HIF Hipoxia Cancer Los tumores solidos, por lo general, existen y progresan en un ambiente de hipoxia; asi se observa que las celulas tumorales son resistentes a la apoptosis y se acompanan de unExpand
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  • Open Access
The HIF1A functional genetic polymorphism at locus +1772 associates with progression to metastatic prostate cancer and refractoriness to hormonal castration.
The hypoxia inducible factor 1 alpha (HIF1a) is a key regulator of tumour cell response to hypoxia, orchestrating mechanisms known to be involved in cancer aggressiveness and metastatic behaviour. InExpand
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  • Open Access
The effects of combination therapy with dutasteride plus tamsulosin on clinical outcomes in men with symptomatic BPH: 4-year post hoc analysis of European men in the CombAT study
CombAT (Combination of Avodart and Tamsulosin) was a randomised, double-blind study in men (n=4844) aged ⩾50 years with a clinical diagnosis of BPH. Patients were randomised to daily tamsulosin 0.4Expand
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Pediatric kidney transplantation: a single center experience with 134 procedures.
Renal transplantation confers substantial benefits on children with end-stage renal disease (ESRD), including improved growth as well as longer and better quality of life. The aim of this study wasExpand
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Molecular study of the PCA3 gene: genotypic analysis of PCA3 polymorphism -845G>A and metastatic prostate cancer.
AIMS The prostate cancer gene 3 (PCA3) is a prostate-specific, non-protein-coding RNA. It is overexpressed in prostate cancer compared with the normal prostate and has a negative expression in otherExpand
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Sialyl-Tn identifies muscle-invasive bladder cancer basal and luminal subtypes facing decreased survival, being expressed by circulating tumor cells and metastases.
OBJECTIVES To evaluate the potential of sialyl-Tn (STn), a cancer-associated glycan antigen present in membrane glycoproteins, to improve a recent molecular model for stratification andExpand
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