A. Fraccari

Publications16
h-index6
Citations127
Highly Influential Citations0
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Potential antitumor agents XIX [1]. Synthesis and antitumor activity of tricyclic compounds related to lotifazole.
The synthesis of phenothiazine and anthraquinone derivatives, bearing at least one fragment present in lotifazole, is reported. Some of the new compounds showed antitumor activity in vitro (P388… Expand
  • 2
Synthesis and potential coanthracyclinic activity of pyridylmethylene and indolylmethylene lactams
The synthesis of pyridylmethylene lactams and indolylmethylene-2-indolinones is reported. These compounds were tested for their cytotoxic and positive inotropic activity. The presence of both the… Expand
  • 11
Synthesis and potential coanthracyclinic activity of substituted 3-(5-imidazo[2,1-b]thiazolylmethylene)-2-indolinones
Summary A compound endowed with coanthracyclinic activity should potentiate the antitumor activity of anthracyclines while counteracting their cardiodepressant effect. We now report the synthesis and… Expand
  • 14
Potential antitumor agents. 25 [1]. Synthesis and cytotoxic activity of 3-(2-chloro-3-indolylmethylene)1,3-dihydroindol-2-ones.
The Knoevenagel reaction between 2-indolinones and 2-chloroindolaldehydes gave 3-(2-chloro-3-indolylmethylene)1,3-dihydroindol-2-ones which were tested as potential antitumor agents on cultures of… Expand
  • 12
Potential antitumor agents. 21. Structure determination and antitumor activity of imidazo[2,1-b]thiazole guanylhydrazones.
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Potential antitumor agents. 24. Synthesis and pharmacological behavior of imidazo[2,1-b]thiazole guanylhydrazones bearing at least one chlorine.
In connection with a previous research dealing with the antitumor activity of imidazo[2,1-b]-thiazole guanylhydrazones, this paper reports the synthesis of new derivatives which were tested for… Expand
  • 36
Potential antitumor agents. XX (1). 6-Anilinoimidazo[2,1-b]thiazoles.
The synthesis of 6-anilinoimidazo[2,1-b]thiazoles, related to the well-known antitumor agent amsacrine, is reported. The cytotoxic activity of the new compounds was evaluated on HeLa cells. Compound… Expand
  • 15
Synthesis and Potential Coanthracyclinic Activity of Substituted 3‐(5‐Imidazo[2,1‐b]thiazolylmethylene)‐2‐indolinones.
  • 1
Potential coanthracyclinic activity of pyridylmethylene-2-indolinones.
The paper reports the cytotoxic activity of pyridylmethylene-2-indolinones previously described as cardiotonics and the synthesis of three analogs of the most potent cytotoxic agent. Some of these… Expand
  • 3
Potential antitumor agents. XXII. Synthesis and cytotoxic activity of imidazo [2,1-b]thiazole adamantylthioureas.
A series of imidazo[2,1-b]thiazole adamantylthioureas (3a-f) was synthesized by reaction of the methylsulfanylethylamines 2a-f (prepared in turn from the hydroxymethylimidazo[2,1-b]thiazoles 1a-f and… Expand
  • 2