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Toxoplasma gondii Dysregulates IFN-γ-Inducible Gene Expression in Human Fibroblasts: Insights from a Genome-Wide Transcriptional Profiling1
TLDR
Using a genome-wide microarray analysis, a complete dysregulation of IFN-γ-inducible gene expression is shown in human fibroblasts infected with Toxoplasma, indicating that other stimuli produced during infection may also regulate these genes.
Antibodies against the gH/gL/UL128/UL130/UL131 Complex Comprise the Majority of the Anti-Cytomegalovirus (Anti-CMV) Neutralizing Antibody Response in CMV Hyperimmune Globulin
TLDR
It is demonstrated that the major neutralizing antibody response is directed at the gH/gL/UL128/UL130/UL131 complex, suggesting little role for anti-gB antibodies in CMV-HIG neutralization.
Early life history of Hemigrapsus sanguineus, a non-indigenous crab in the Middle Atlantic Bight (USA)
TLDR
Results of the investigation showed that the spawning season of H. sanguineus continues for at least 4 mo in the southern Middle Atlantic Bight, which is considerably longer than the spawning seasons of CO-occurring native crabs.
Toxoplasma secreting Cre recombinase for analysis of host-parasite interactions
TLDR
A Toxoplasma gondii strain will permit the use of site-specific recombination to study the host-parasite interactions of this organism and efficiently injects a Cre fusion protein into host cells.
RNA analysis by biosynthetic tagging using 4-thiouracil and uracil phosphoribosyltransferase.
TLDR
This chapter updates the original RABt protocol and addresses methodological details associated with RABT that were beyond the scope or space allotment of the initial report.
Mechanism for neutralizing activity by the anti-CMV gH/gL monoclonal antibody MSL-109
TLDR
Viral mutants resistant to MSL-109 were generated and the epitope of this neutralizing antibody was mapped on the model of the structure of CMV gH, revealing a previously undescribed aspect of viral entry that may be susceptible to therapeutic intervention.
Phase 2 Randomized, Double-Blind, Placebo-Controlled Trial of RG7667, a Combination Monoclonal Antibody, for Prevention of Cytomegalovirus Infection in High-Risk Kidney Transplant Recipients
TLDR
In high-risk kidney transplant recipients, RG7667 was well tolerated, numerically reduced the incidence of CMV infection within 12 and 24 weeks posttransplant, delayed time to CMV viremia, and was associated with less CMV disease than the placebo.
Infection with Toxoplasma gondii Bradyzoites Has a Diminished Impact on Host Transcript Levels Relative to Tachyzoite Infection
TLDR
Results suggest that bradyzoites lead a more stealthy existence within the infected host cell, and those changes that did occur were almost all of lower magnitude than those induced by tachyzoites.
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