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Association of Leisure-Time Physical Activity With Risk of 26 Types of Cancer in 1.44 Million Adults.
TLDR
Leisure-time physical activity was associated with lower risks of many cancer types, and most of these associations were evident regardless of body size or smoking history, supporting broad generalizability of findings. Expand
Breast cancer risk in relation to different types of hormone replacement therapy in the E3N‐EPIC cohort
TLDR
The results suggest that, when combined with synthetic progestins, even short‐term use of estrogens may increase breast cancer risk, and Micronized progesterone may be preferred to synthetic progESTins in short-term HRT. Expand
Postmenopausal breast cancer risk and dietary patterns in the E3N-EPIC prospective cohort study.
TLDR
Adherence to a diet comprising mostly fruits, vegetables, fish, and olive/sunflower oil, along with avoidance of Western-type foods, may contribute to a substantial reduction in postmenopausal breast cancer risk. Expand
Postmenopausal serum androgens, oestrogens and breast cancer risk: the European prospective investigation into cancer and nutrition.
TLDR
The results have shown that, among postmenopausal women, not only elevated serum oestrogens but also serum androgens are associated with increased breast cancer risk, and caution against the use of DHEA(S), or other androgens, for post menopausal androgen replacement therapy. Expand
Reproductive risk factors and endometrial cancer: the European Prospective Investigation into Cancer and Nutrition
TLDR
A reduction in risk of endometrial cancer with factors associated with a lower cumulative exposure to estrogen and/or higher exposure to progesterone, such as increasing number of FTPs and shorter menstrual lifespan is confirmed and support an important role of hormonal mechanisms inendometrial carcinogenesis. Expand
Serum sex steroids in premenopausal women and breast cancer risk within the European Prospective Investigation into Cancer and Nutrition (EPIC).
TLDR
The hypothesis that elevated blood concentrations of androgens are associated with an increased risk of breast cancer in premenopausal women is supported. Expand
Unequal risks for breast cancer associated with different hormone replacement therapies: results from the E3N cohort study
TLDR
The findings suggest that the choice of the progestagen component in combined HRT is of importance regarding breast cancer risk; it could be preferable to use progesterone or dydrogesterone. Expand
Serum Sex Steroids in Premenopausal Women and Breast Cancer Risk Within the European Prospective Investigation into Cancer and Nutrition (EPIC)
TLDR
A case-control study nested within the European Prospective Investigation into Cancer and Nutrition cohort to examine associations among premenopausal serum concentrations of sex steroids and subsequent breast cancer risk found no statistically significant association with serum levels. Expand
Menarche, menopause, and breast cancer risk: individual participant meta-analysis, including 118 964 women with breast cancer from 117 epidemiological studies
TLDR
The effects of menarche and menopause on breast cancer risk might not be acting merely by lengthening women's total number of reproductive years, and endogenous ovarian hormones are more relevant for oestrogen receptor-positive disease than for ostrogens receptor-negative disease and for lobular than for ductal tumours. Expand
Postmenopausal Hormone Therapy and Risk of Idiopathic Venous Thromboembolism: Results From the E3N Cohort Study
TLDR
Oral estrogen therapy increases venous thromboembolism risk among postmenopausal women using hormone therapy and route of estrogen administration and concomitant progestogens type are 2 important determinants of thrombotic risk. Expand
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