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Self-cleavage of plus and minus RNA transcripts of avocado sunblotch viroid.
Self-cleavage of both plus and minus RNA transcripts of the 247-residue avocado sunblotch viroid (ASBV), prepared from tandem dimeric cDNA clones, occurs specifically at two sites in each transcriptExpand
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Self-cleavage of plus and minus RNAs of a virusoid and a structural model for the active sites
Virusoids are circular single-stranded RNAs dependent on plant viruses for replication and encapsidation. Virusoid replication appears to involve longer-than-unit-length plus and minus RNAs,Expand
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Slow peptide bond formation by proline and other N-alkylamino acids in translation
Proteins are made from 19 aa and, curiously, one N-alkylamino acid (“imino acid”), proline (Pro). Pro is thought to be incorporated by the translation apparatus at the same rate as the 19 aa, evenExpand
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Non-radioactive hybridization probes prepared by the chemical labelling of DNA and RNA with a novel reagent, photobiotin.
A photo-activatable analogue of biotin, N-(4-azido-2-nitrophenyl)-N'-(N-d-biotinyl-3-aminopropyl)-N'-methyl-1,3- propanediamine (photobiotin), has been synthesized and used for the rapid and reliableExpand
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Self-cleavage of virusoid RNA is performed by the proposed 55-nucleotide active site
Virusoids are circular single-stranded RNAs dependent on plant viruses for replication and encapsidation. Recently, we showed that an in vitro-synthesized RNA containing 273 nucleotides of theExpand
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External guide sequences for an RNA enzyme.
Ribonuclease P (RNase P) from Escherichia coli or its catalytic RNA subunit can efficiently cleave small RNA substrates that lack the conserved features of natural substrates of RNase P if anExpand
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Self-cleaving viroid and newt RNAs may only be active as dimers
Avocado sunblotch viroid (ASBV) is a 247-nucleotide, single-stranded, circular RNA1. It is considered to replicate via a rolling-circle mechanism2–4 in which circular, monomeric plus and minus RNAsExpand
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Programming peptidomimetic syntheses by translating genetic codes designed de novo
Although the universal genetic code exhibits only minor variations in nature, Francis Crick proposed in 1955 that “the adaptor hypothesis allows one to construct, in theory, codes of bewilderingExpand
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DNA methylation, genomic imprinting, and mammalian development.
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