Mechanism of chemoresistance mediated by miR-140 in human osteosarcoma and colon cancer cells
Findings indicate that miR-140 is involved in the chemoresistance by reduced cell proliferation through G1 and G2 phase arrest mediated in part through the suppression of HDAC4.
Molecular mechanism of chemoresistance by miR-215 in osteosarcoma and colon cancer cells
It is indicated that miR-215, through the suppression of DTL expression, induces a decreased cell proliferation by causing G2-arrest, thereby leading to an increase in chemoresistance to MTX and TDX.
Prognostic Values of microRNAs in Colorectal Cancer
Hsa-miR-200c may be a potential novel prognostic factor in colorectal cancer patients because of its strongly associated with the mutation status of the p53 tumor suppressor gene.
Microsatellite instability and Beta2-Microglobulin mutations as prognostic markers in colon cancer: results of the FOGT-4 trial
The risk of late disease relapse was significantly lower in patients with MSI-H compared with MSS colon cancer and B2M mutations should be evaluated as a potential prognostic marker in future clinical trials.
Validation of biomarkers associated with 5-fluorouracil and thymidylate synthase in colorectal cancer.
In this study, the in vivo significance of several marker genes in terms of prognostic potential was evaluated using colorectal cancer patient samples and Kaplan-Meier survival analysis indicated that MBD4 was a key protein involved in DNA methylation.
Thymidylate synthase expression and prognosis of patients with gastrointestinal cancers receiving adjuvant chemotherapy: a review
- A. Formentini, D. Henne-Bruns, M. Kornmann
- Medicine, BiologyLangenbeck's archives of surgery (Print)
- 12 August 2004
Patients with gastrointestinal cancers that express high TS levels have a poor prognosis with regard to fluoropyrimidine-based palliative chemotherapy or complete primary tumour resection, while patients with low TS levels appear to benefit, especially, from adjuvant fluoropyridine- based chemotherapy after completePrimary tumours resection.
Carcinoma of the head of the pancreas arising from the uncinate process
- D. Birk, M. Schoenberg, F. Gansauge, A. Formentini, G. Fortnagel, H. Beger
- MedicineBritish Journal of Surgery
- 1 April 1998
The purpose of this prospective study was to evaluate the clinical appearance of CUP and to compare findings with those of patients with carcinoma in the ventral aspect of the pancreatic head (VPC), which represents the most frequent localization.
Expression of interleukin-4 and interleukin-13 and their receptors in colorectal cancer
- A. Formentini, P. Braun, H. Fricke, K. Link, D. Henne-Bruns, M. Kornmann
- Biology, MedicineInternational Journal of Colorectal Disease
- 24 March 2012
Multivariate analysis revealed that besides pT classification and tumor recurrence, IL-13 expression was an independent prognostic factor for overall survival and these interleukins and their receptors may become attractive targets for the treatment of colorectal cancer.
Regional chemotherapy of non-resectable liver metastases from colorectal cancer – literature and institutional review
The high response rates, the long survival times, the possibility of achieving 5-year-survival either by HAI alone or by resection after down staging with HAI all sum up to the evidence that HAI could be the primary choice of treatment for CRLM.