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Mechanism of chemoresistance mediated by miR-140 in human osteosarcoma and colon cancer cells
TLDR
Findings indicate that miR-140 is involved in the chemoresistance by reduced cell proliferation through G1 and G2 phase arrest mediated in part through the suppression of HDAC4.
Molecular mechanism of chemoresistance by miR-215 in osteosarcoma and colon cancer cells
TLDR
It is indicated that miR-215, through the suppression of DTL expression, induces a decreased cell proliferation by causing G2-arrest, thereby leading to an increase in chemoresistance to MTX and TDX.
Prognostic Values of microRNAs in Colorectal Cancer
TLDR
Hsa-miR-200c may be a potential novel prognostic factor in colorectal cancer patients because of its strongly associated with the mutation status of the p53 tumor suppressor gene.
Prognostic Values of microRNAs in Colorectal Cancer
The functions of non-coding microRNAs (miRNAs) in tumorigenesis are just beginning to emerge. Previous studies from our laboratory have identified a number of miRNAs that were deregulated in colon
Validation of biomarkers associated with 5-fluorouracil and thymidylate synthase in colorectal cancer.
TLDR
In this study, the in vivo significance of several marker genes in terms of prognostic potential was evaluated using colorectal cancer patient samples and Kaplan-Meier survival analysis indicated that MBD4 was a key protein involved in DNA methylation.
Microsatellite instability and Beta2-Microglobulin mutations as prognostic markers in colon cancer: results of the FOGT-4 trial
TLDR
The risk of late disease relapse was significantly lower in patients with MSI-H compared with MSS colon cancer and B2M mutations should be evaluated as a potential prognostic marker in future clinical trials.
Carcinoma of the head of the pancreas arising from the uncinate process
TLDR
The purpose of this prospective study was to evaluate the clinical appearance of CUP and to compare findings with those of patients with carcinoma in the ventral aspect of the pancreatic head (VPC), which represents the most frequent localization.
Thymidylate synthase expression and prognosis of patients with gastrointestinal cancers receiving adjuvant chemotherapy: a review
TLDR
Patients with gastrointestinal cancers that express high TS levels have a poor prognosis with regard to fluoropyrimidine-based palliative chemotherapy or complete primary tumour resection, while patients with low TS levels appear to benefit, especially, from adjuvant fluoropyridine- based chemotherapy after completePrimary tumours resection.
Regional chemotherapy of non-resectable liver metastases from colorectal cancer – literature and institutional review
TLDR
The high response rates, the long survival times, the possibility of achieving 5-year-survival either by HAI alone or by resection after down staging with HAI all sum up to the evidence that HAI could be the primary choice of treatment for CRLM.
Expression of interleukin-4 and interleukin-13 and their receptors in colorectal cancer
TLDR
Multivariate analysis revealed that besides pT classification and tumor recurrence, IL-13 expression was an independent prognostic factor for overall survival and these interleukins and their receptors may become attractive targets for the treatment of colorectal cancer.
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