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Characterization of the Potent and Highly Selective A2A Receptor Antagonists Preladenant and SCH 412348
The adenosine A2A receptor has been implicated in the underlying biology of various neurological and psychiatric disorders, including Parkinson's disease (PD) and depression. Preladenant and SCHExpand
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The antinociceptive and anxiolytic-like effects of the metabotropic glutamate receptor 5 (mGluR5) antagonists, MPEP and MTEP, and the mGluR1 antagonist, LY456236, in rodents: a comparison of efficacy
RationaleModulation of metabotropic glutamate receptor (mGluR) subtypes represents a novel approach for the treatment of neurological and psychiatric disorders.ObjectivesThis study was conducted toExpand
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Blockade of adenosine A2A receptors by SCH 58261 results in neuroprotective effects in cerebral ischaemia in rats
BLOCKADE of adenosine receptors can reduce cerebral infarct size in the model of global ischaemia. Using the potent and selective A2A adenosine receptor antagonist, SCH 58261, we assessed whether A2AExpand
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Mechanism and pressor relevance of the short-term cardiovascular and renin excitatory actions of the selective A2A-adenosine receptor agonists.
Selective A2A adenosine receptor agonists are potent vasodilators that reduce blood pressure and induce marked increments in heart rate and plasma renin activity (PRA). To examine the mechanisms andExpand
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Cardiovascular pharmacology of the A2A adenosine receptor antagonist, SCH 58261, in the rat.
We characterized the in vivo cardiovascular profile of SCH 58261, 7-(2-phenylethyl)-5-amino-2-(2-furyl)-pyrazolo-[4,3-e]-1,2, 4-triazolo[1,5-c] pyrimidine, a selective A2A adenosine receptorExpand
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Telemetry monitoring of hemodynamic effects induced over time by adenosine agonists in spontaneously hypertensive rats.
Using the telemetry system in spontaneously hypertensive rats (SHR), we evaluated the hemodynamic effects of four adenosine analogs having different selectivity for A1 and A2a adenosine receptorExpand
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Distribution of physical clusters
A general formalism is developed to obtain series expansions of the average number of physical clusters of particles in the framework of Mayer's theory. The special case of lattice systems isExpand
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Characterization of the Potent and Highly Selective A 2 A Receptor Antagonists Preladenant and SCH 412348 in Rodent Models of Movement Disorders and Depression
Department of Neurobiology, Schering-Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA. (RAH, GBV, JEL, MEC-W, GAH, LEP, CF, YZ, EMP, JCH) Department of Neurobiology,Expand
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α1 Adrenoceptor subtype mediates noradrenaline induced contraction of the human internal mammary artery: radioligand and functional studies
Study objective – The aim was to evaluate the characteristics of α adrenergic binding sites on human internal mammary arteries and the α adrenoceptor mediated vasoconstrictor response toExpand
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Livelli critici di ozono ed effetti sulle piante in Italia
The article outlines the results of a joint study by La Sapienza University of Rome, Federico II University of Naples and CESI of Milan, under a programme agreement between the Environment MinistryExpand
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